Endocrine Abstracts

Introduction: Cortisol activates lipolysis in adipose tissue resulting in the release of free fatty acids into the circulation, it also activates cholesterol and triglycerides synthesis. The consequence is an increase in total circulating cholesterol and triglycerides with their inherent risks on the cardiovascular system. The aim of our work was to assess the prevalence and characteristics of dyslipidaemia in Cushing’s syndrome (CS).Material and me...

Introduction: Patients with Cushing’s syndrome (CS) are prone to hypertension as cortisol stimulates renal reabsorption of sodium and enhances vascular sensitivity to catecholamine and angiotensin II. This explains the frequency of hypertension in patients with CS. The aim of our work was to assess the prevalence and characteristics of hypertension in CS.Material and methods: This is a retrospective study concerning 51 CS (44F/7M) in whom we looked ...

Introduction: Pituitary apoplexy is a rare endocrine emergency characterized by the sudden onset of severe headaches, vomiting, visual abnormalities and pituitary dysfunction secondary to an acute hemorrhage or infarction within a pituitary adenoma.Subjects and methods: We report a retrospective study from 2000 to 2014 of 23 cases with pituitary apoplexy. Their mean age was 38.7±14.8 years, with a male to female ratio of 2:1.R...

Klinefelter’s syndrome (KS) is the most frequent form of sex chromosome aneuploidy. The classic form of KS is associated with a 47,XXY karyotype. Mosaic forms of KS are thought to occur in approximately 10% mainly in the form of 46,XX/47,XXY. Other forms of mosaicism are rare among which the 46,XX/47,XXY form is very rare and can manifest as an ambiguous genitalia at birth as reported in our case.A full term child presented at birth an hypospadias w...

Insulinoma is the most common cause of hypoglycemia related to endogenous hyperinsulinism in adults. It is very rare in pregnancy, fewer than 30 cases of insulinoma presenting in pregnancy have been reported so far and it’s managment is very challenging. We raported here the case of a pregnant women aged 35 years presenting an insulinoma.The diagnosis was made 1 year ago in the presence of hypoglycemia, high levels of inulin and C-peptide and a 10 m...

Neurofibromatosis type 1 is a genetic multisystemic disorder involving the skin, the central and peripheral nervous systems, bones, and the cardiovascular and endocrine systems. We report 2 cases of type 1 neurofibromatosis in 2 patients aged 27 and 23 years respectively. The dermatological lesions (neurofibroma and café au lait spots) were the revealing symptoms. Cerebral MRI revealed a glioma of the optic chiasm developing along the Optic nerves. NF1 has been known for ...

Abstract: Gliomas of the optic pathways are rare tumors that are mainly seen in children. We report the case of a 4 year old boy followed since the age of 6 months for a nystagmus. It is a boy born at term by vaginal way resulting from parents not consanguineous, the parents noted the nystagmus when their child was 6 months old. After opinion of the ophthalmologist, the child is treated only by optical correction, it is only at the age of 4 years following the installation of ...

Introduction: The occurrence of primary pituitary tumour and cerebral schwannoma in the same person is very rare. Only few cases have been reported so far. The mechanism of this association is still unclear.Aim: Our aim is to report a man with two different brain tumours: a prolactinoma and a cerebellopontine schwannoma in order to discuss the possible mechanism of multiple neoplasms arising in the same person.Case report: A man ag...

Chlorpyrifos (CPF) is a worldwide used organophosphate insecticide for controlling many types of pests in the household, farm and residential settings. It has the potential to negatively affect the reproductive system and fertility. Nigella sativa has been used both as seeds or oil to promote health and fight disease. Hence, the present work was undertaken to evaluate the possible protective role of Nigella sativa oil (NSO) against chlorpyrifos induced reproductive toxicity in...

Introduction: Pituitary somatotrop adenomas are very rare in children and adolescents. They are supposed to be more invasive (invasion of cavernous sinuses or meninges±compression of adjacent neural structures) than adults’ones. We aimed to analyze their characteristics, and their complications.Patients and subjects: are studied subjects whose clinical symptoms began before 20 years old. They all had biological, hormonal, ophthalmological, radi...