Endocrine Abstracts

Introduction: No consensus guideline on the treatment of hypoparathyroidism. Hypoparathyroidism is a disease characterized by hypocalcaemia and insufficient PTH. Conventional therapy includes calcium and active vitamin D supplementation, often in large doses.Case report: A 31-year-old woman presented with hypercalcemia. Serum calcium and phosphorus levels were 10.5 and 2.56 mg/dl respectively. The serum PTH level was increased (1619 pg/ml). The serum 25-...

Context: Irisin is secreted by skeletal muscles into circulation and proposed to regulate energy homeostasis and hold therapeutic potential in diabetes and obesity.Objective: The aim of this study was to evaluate the effects of acute exercise training (6 week) on circulating plasma irisin in adult mens.Design and setting: This was a cross-sectional study conducted in a university hospital.Participants: A tota...

Introduction: Here, we present a case of epithelial breast cancer releasing iPTH thereby causing MAH.Case report: A 48-year-old woman with metastatic breast cancer was consulted for hypercalcemia. Previous medical record was insignificant except for nephrolitiasis. She had a left mastectomy+left axillary lymph node dissection in another hospital. Prior to surgery no calcium levels were obtained. Pathology revealed infiltrative ductal carcinoma. Postopera...

Introduction: Involvement of different tissues and organs may be seen during the course of Graves’ disease (GD). We here aimed to present a case with GD and lung mass whose lung lesion disappeared after recieving antithyroid treatment.Case report: A 60 year old man admitted to our hospital with back pain. His thorax computed tomography (CT) revealed a 1.5×3 cm mass in lower right lobe. He was consultated by our clinic preoperatively before thor...

Background and aim: The clinical significance of papillary thyroid microcarcinoma (PTMC) is debatable. The purpose of this study is to analyse the clinicopathological characteristics of patients with PTMC and document the risk factors for poor prognosis.Materials and methods: Eighty-eight patients (18 males, 70 females) were included in the study. Clinical and laboratory parameters were recorded.Results: The mean age of the patient...

We report an 18 years old female with hepatomegaly and elevated liver function tests. She had been diagnosed with Type 1 diabetes mellitus when she was 13 years old. She was referred to our division because of diabetic ketoacidosis. Evaluation of her previous records revealed the presence of liver function abnormalities for 4 months. At physical examination she had an enlarged liver. A1c level was 13%. She was treated initially with intravenous insulin. Following the achieveme...

Background and aims: The type 1 DM patients who are GAD antibody positive have more risk of autoimmune thyroid disease than who are negative. In patients with autoimmune thyroid disease there is a significantly increased risk of anti-pancreatic autoimmune response as shown by increased GAD antibody positivity compared to normal population. However, the linkage between IA2 and thyroid autoimmunity is evaluated in one studied. Our aim is to evaluate the frequency of presence of ...

Objective: Thiazolidinediones offer promise as oral insulin-sensitizing agents. Peroxisome proliferator-activated receptor-g (PPARg), a member of the steroid receptor superfamily, play a pivotal role in the differentiation of adipocytic cells. Osteoblasts and adipocytes are derived from common bone marrow stromal cells that play crucial roles in the generation of osteoclasts. Activation of peroxisome proliferator-activated receptor-g (PPARg) induces adipogenic differentiation ...

Objectives-Aim: Oxidized low-density lipoprotein (LDL) seems to play an important role in the etiology of atherosclerosis. They stumulate atherosclerosis. Glucocorticoids decrease LDL degradation and expression of LDL receptor. Morever insulin resistance in glucocorticoid excess state may contribute to LDL oxidation changes. The aim of this study was to investigate, the LDL oxidation in glucocorticoid excess state and the effect of atorvastatin on LDL oxidation.<p class="...

Objectives-Aim: Oxidized low-density lipoprotein (LDL) seems to play an important role in the etiology of atherosclerosis. They stumulate atherosclerosis. Oestradiol and other oestrogens have been shown to be powerful antioxidants in vitro when they are added to ldl oxidation mixtures. Oestrogen deficiency states are increases LDL oxidation. The aim of this study is investigate the effect of growth hormone on LDL oxidation in estrogen deficiency.Materia...