Endocrine Abstracts

Objective: Human growth hormone (hGH) stimulates bone formation and have been proposed as therapeutic agents for osteoporosis. We have examined the effects of hGH on femoral and vertebral bone strength in osteoporotic rats.Methods: Thirty-five Sprague-Dawley rats were assigned to study in three groups: (1) Normal rats (without ovariectomy and corticosteroid therapy) (2) Osteoporosis group: ovariectomized (OVX) or with glucocorticoid induced osteoporotic ...

Introduction: CNC (Carney complex) is a rare inherited autosomal dominant syndrome characterized by prominent pigmented lesions on the skin and mucosal surfaces, cardiac and noncardiac myxomatous tumors, and multiple endocrine neoplasms. About 70% of cases have a family history, while the remaining 30% occur sporadically as a result of de novo mutation. Two genetic loci linked to CNC have been found: the CNC1 gene on chromosome 17q22-24, which encodes the regulatory subunit (R...

Prevalence of Paget’s disease (PD) of bone as well as clinical and demographical presentation may differ between the populations.Aim: In this study we evaluate clinical and demographical parameters of Paget’s disease patients followed from endocrinology clinics in Turkey.Method: An invitation was sent to all tertiary endocrinology clinics to complete a survey on demographic clinical, laboratory parameters, treatment modal...

Aim: To compare macular pigment optical density (MPOD) in diabetic and non-diabetic patients by using heterochromatic flicker photometry and to investigate the correlation of MPOD with glycosylated hemoglobin (HbA1C), serum lipid levels and vitamin D levels.Methods: Sixty-seven patients with 10/0 visual acuity were divided into group 1 (controls, n: 35) and group 2 (diabetics without retinopathy, n: 32). MPOD was measured with a heteroc...

Background and aim: Incidentally discovered adrenal masses (adrenal incidentalomas (AI)), generally 1 cm or more in diameter, are mostly benign and asymptomatic and are often considered as nonfunctional tumors. The aim of this study was to perform the imaging characteristics, endocrinologic screening and histologic diagnoses of adrenal incidentaloma cases encountered in our institute.Methods: This retrospective evaluation of patients with AI includes 543...

Context: Irisin, a newly discovered hormone, is secreted by skeletal muscles into circulation. It is proposed to regulate energy homeostasis and hold therapeutic potential in diabetes and obesity.Objective: We aimed to investigate the association of irisin and uncoupling protein 1 (UCP1) with gestational diabetes mellitus (GDM).Design and Setting: This was a cross-sectional study conducted in a university hospital.<p class="abs...

Introduction: Diabetes is characterized by an increase in abdominal fat. This results in a decrease in lean body mass and increase in insulin resistance. In this study, we aimed to evaluate the possible relationship between body composition and insulin regimen modality in type 1 diabetic patients.Materials and methods: Ninety-two type 1 diabetic patient followed in our institution were included in the study. Patients were classified into two groups accor...

Background: Primary empty sella is an anatomical term defining the herniation of subarachnoid space within the sella turcica without an underlying factor such as pituitary tumor, surgery, irradiation or trauma.Patients and methods: We retrospectively evaluated clinical, hormonal and radiological data of the patients with primary empty sella syndrome followed in our institution between 2001 and 2012.Results: Ninety-four patients (80...

Introduction: The growth promoting effects of GH and IGF1 has lead to increasing number of cancer surveillence studies in acromegaly so far. We herein aimed to present the prevalance of cancer in acromegaly patients followed in our institution.Patients and design: We retrospectively analyzed medical records of 151 patients with acromegaly (83 females) followed in our department from 2001 to 2012.Results: Overall, cancer was detecte...

Introduction: Differentiated thyroid carcinoma (papillary and follicular) being the most common type of thyroid malignancy (80%), originates from the thyroglobuline secreting follicular cells. Medullary thyroid cancer derived from parafollicular C-cells producing calcitonin is relatively rare (5–10%). In this report we aimed to present a case with simultaneous papillary and medullary carcinoma in the same thyroid nodule.Case report: Sixty nine year ...