Endocrine Abstracts

Background: Endocrine hypertension accounts for around 3% of the secondary forms of hypertension and screening of young hypertensive patients for secondary causes is mandatory.Aim: To present difficulties in endocrine assessment of arterial hypertension in people younger than 40 years.Patients and methods: Twenty-two patients (15 M/7 F), aged 27.1±7.7 years (range:16-40 years), with systemic hypertension (systolic blood pressu...

Introduction: Remission rate in microprolactinomas after treatment with dopamine agonists (DA) is variable, from about 25% in bromocriptine-treated patients to 46% in those treated with cabergoline.Patients: We retrospectively studied the remission rate in 98 patients with prolactinomas ≤1 cm evaluated in 1982–2009 in our department and treated with DA for at least 1 year.Results: Mean age of patients is 26.5±8 year...

Introduction: Incidentaloma is a randomly discovered tumor with no apparent secretor activity. The term is mainly used for hypophysis and adrenals. There are relatively few situations where a patient has more than one such mass.Aim: To present the case of a patient with three tumors: a pituitary mass and bilateral adrenal masses, with clinical manifestations of Cushing’s syndrome.Case report: A 37-year-old female patient who h...

Introduction: Congenital adrenal hyperplasia is a group of autosomal recessive diseases, caused by mutations in the enzymes implicated in the synthesis of cortisol. In females, the classical pattern is characterized by progressive virilisation, short stature and in severe cases, by salt wasting in the newborn.Results: We present the case of a 14 years old female patient, who was referred to our clinic for primary amenorrhea. Her personal and family histo...

Aim: To evaluate the clinical efficacy of androgen replacement therapy with oral or intramuscular (i.m.) testosterone undecanoate (T.U.) in male patients with central hypogonadism.Patients and methods: We retrospectively evaluated 40 patients with hypogonadotropic hypogonadism: 29 with pituitary tumors or craniopharyn-giomas, 11 with non-tumoral hypogonadism (median age 47 years, range 20–62), before and after androgen replacement therapy, with the ...

It has been generally believed that clinically functioning pituitary adenomas are highly specialized neoplastic lesions, which produce a unique hormone. Increasing body of evidence argue against this concept, since about half of prolactinomas (PRM) and approximately 60% of TSH-secreting adenomas are multihormonal and 30–40% of GH-secreting adenomas co-secrete PRL. Most of classically considered null cell adenomas have been proved to be immunohistochemical positive for gon...

Objectives: Pituitary adenomas usually do not over-secrete gonadotropins in the bloodstream, although they may stain for gonadotropins. Our study aimed to assess whether the pre-operative gonadotropin level in CSF could be used as a marker of the pituitary tumour’s gonadotropin secretion.Patients and methods: 359 patients with pituitary adenomas, diagnosed between 1979 and 2005 in the Institute of Endocrinology, Bucharest, were evaluated before pitu...

Introduction: The current revised medullary thyroid carcinoma (MTC) guidelines don’t specify reference ranges of basal (bCT) or stimulated serum calcitonin (sCT) levels for the diagnosis of MTC. These are important for early diagnosis and correct management.Objective: We aimed to set gender specific thresholds for bCT and sCT for MTC diagnosis.Patients and methods: CT samples during calcium-stimulation test (2...

Background: Growth hormone, age, sex, genetics or nutrition status play an important role in insuline-like growth factor 1 (IGF-1) liver production and serum levels. Currently, there is no IGF-I reference range for Romanian population.Aim: To define sex- and age-adjusted reference values for serum IGF-I measured by an automated chemiluminescence immunoassay in adult Romanian population of healthy subjects.Methods: The study include...

IntroductionProlactinomas are the most common hormone-secreting pituitary tumours encountered in the clinic. They are usually treated with dopamine agonists (DA): bromocriptine (BRC) and cabergoline (CAB), which are highly effective in the majority of cases. DA resistance is the failure to achieve normal levels of prolactin and, or reduction of the adenoma with at least 50%.Aimto assess the prevalence of the ...