Endocrine Abstracts

Introduction: New-onset hyperandrogenism is rare in postmenopausal women and is usually associated with causes such as ovarian hyperthecosis, androgen-secreting tumor or medication. Patients with hyperandrogenism and breast cancer need a special attention when choosing the treatment.Case history: A 46-year old woman diagnosed with hormone receptor-positive breast cancer at 37 years old, for which she underwent surgery, chemotherapy, radiotherapy and horm...

Background: Acromegaly is characterized by increased prevalence of fragility vertebral fractures. Nonetheless, there are no clear recommendations for prevention of acromegalic osteopathy. Both bone mineral density (BMD) and trabecular bone score (TBS) lack clear evidence as prognostic factors for vertebral fractures (VF).Material and Methods: We performed an observational study on 31 acromegalic patients recruited prospectively. They were tested for alka...

Introduction: We describe a patient with Cushing’s disease caused by a pituitary macroadenoma treated by double transsphenoidal surgery, stereotactic radiosurgery and steroidogenesis inhibitors and also the challenging management of a patient with multiple comorbidities, including chronic leg ulcers, which are related to increased morbidity and health costs.Case report: In October 2019, a 67-year-old patient presented with intense headache, left tem...

Background: Higher anti-Müllerian hormone (AMH) values are associated with polycystic ovary syndrome (PCOS) and AMH is proposed as a marker of PCOS, however, the optimal diagnostic threshold is not yet defined.Aim: To study the significant correlations of AMH in PCOS and the accuracy and threshold of AMH for the PCOS diagnosis in Romania.Subjects and methods: Serum AMH, TT, LH, FSH, fasting glucose and insulin (Ins), HOMA-IR a...

Objective: To evaluate the comparative effects of different glucocorticoid treatments on growth and sexual maturation in patients with congenital adrenal hyperplasia.Patients and methods: We conducted a retrospective observational cohort study in 78 patients (60 girls, 18 boys) diagnosed with congenital adrenal hyperplasia (CAH), followed-up for a period of 5 years. The majority had 21-hydroxylase deficiency (75 patients), 2 had 11-β hydroxylase def...

Case presentation: Mrs. S presented in an endocrine clinic for fatigue, weight loss, restlessness and goiter. She was obese with a BMI of 51 kg/mp, hypertensive and had a medium size, nontender goiter. Lab test revealed hyperglycaemia, suppressed TSH (<0.03mUI/L), on two separate occasions, mid-normal fT4 and T3. Thyroid ultrasound revealed multinodular goiter. A diagnosis of polynodular goiter with subclinical hyperthyroidism was made and patient was commenced on thiamazo...

Introduction: Matrix metalloproteinase-9 (MMP-9) is a zinc dependent proteolytic enzyme used by cells for degradation of the extracellular matrix during invasion and migration. There are only a few reports regarding the role played by MMP-9 in papillary thyroid carcinoma (PTC).Aim: To evaluate the association between MMP-9 secretion, reflected by preoperative serum levels and the histopathological features of thyroid tumors.Materia...

10% of patients with adrenal tumours have bilateral lesion.Objective: To evaluate clinical, imagistic and hormonal characteristics of bilateral adrenal tumours.Design and mehods: Retrospective series of 150 consecutive patients (104F, 46M) with bilateral adrenal tumours with maximal diameter of at least 1 cm, evaluated from 2001 to 2015 in a tertiary endocrinology clinic with clinical, hormonal and imagistic methods.<p class="a...

Background: The role of circulating Galectin-3 as a potential biomarker of malignancy in thyroid disease remains inconclusive. In a previous pilot study we reported a significant difference between serum Gal-3 levels in papillary thyroid carcinoma (PTC) patients and those with benign pathology, but no association with tumor aggressiveness.Aim: We measured serum Gal-3 levels in a larger series of patients submitted to thyroidectomy, in order to assess its...

Thyroid carcinoma is the most common endocrine malignancy and represents ~1% of all types of human cancer.Objective: As the molecular pathogenesis of thyroid cancer still remains to be clarified, the goal of our study was to find new molecular markers that could improve the diagnostics, follow-up protocols, treatment outcome, prognosis and the quality of life of differentiated thyroid cancer patients.Subjects and methods: Matched t...