Endocrine Abstracts

Aim: Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are prognostic markers of differentiated thyroid cancers. In our study we evaluated NLR, PLR and C-reactive protein for predicting the occurence of differentiated thyroid cancer. This is the first study that compares NLR and PLR to C-reactive protein indifferantiated thyroid cancer not only papillary cancer but also folliculer cancer.Materials and Method: This study includes 51 pa...

This work focuses on the characterization of circulating tumor cells(CTCs) captured from the blood of cancer patients using a microfluidic chip functionalized with an antibody against the epithelial cell adhesion molecule (EPCAM). We visualize CTCs captured from the blood of prostate cancer patients taking advantage of the unique tumor-associated marker, prostate specific antigen (PSA). Our data demonstrate that CTCs are detectable preoperatively in patients with early stage, ...

Introduction: Untreated hypothyroidism may lead to decompensation of a patient’s homeostasis. While the association between hypothyroidism and anemia has been noted previously, there are very few, cases of white cell lines and platelet counts being affected by hypothyroidism alone. To demonstrate a rare but significant manifestation of hypothyroidism, we present a unique and interesting case of pancytopenia secondary to severe hypothyroidismCase rep...

Introduction: Untreated hypothyroidism may lead to decompensation of a patient’s homeostasis. While the association between hypothyroidism and anemia has been noted previously, there are very few, cases of white cell lines and platelet counts being affected by hypothyroidism alone. To demonstrate a rare but significant manifestation of hypothyroidism, we present a unique and interesting case of pancytopenia secondary to severe hypothyroidism.Case re...

Background: The identification and characterization of CTCs as part of a minimally invasive “liquid biopsy” has potential as a real-time biomarker in cancer patients. Using blood samples from NET patients, we evaluate the epitope-independent Parsortix, which enriches CTCs based on size and rigidity, and compare to the EpCAM-dependent CellSearch platform.Methods: About 10 patients with histologically confirmed metastatic NET had synchronous 7.5 ...

Objective: The main physiological function of the renin-angiotensin-aldosterone system (RAAS) is the regulation of water and salt homeostasis as well as arterial blood pressure. In addition, the RAAS is proposed to be involved in the pathophysiology of several diseases like hypertension, vascular remodelling, atherosclerosis, insulin resistance and type 2 diabetes mellitus. In a cohort study in north-east Germany, we investigated the association of plasma renin- (PRC) or plasm...

Objectives: Molecular techniques are becoming increasingly important for the management of thyroid nodules. In particular, next-generation sequencing (NGS) can assess multiple predictive biomarkers simultaneously, enabling more accurate pre-operative risk stratification for patients with indeterminate fine-needle aspirates and identifying specific molecular alterations for targeted therapy in patients affected by advanced, radioactive iodine refractory carcinomas. To meet thes...

ObjectiveRadioactive iodine (RAI) therapy is widely used in both diagnosis and treatment of benign and malignant thyroid diseases. It is generally a well tolerated therapy. Bone marrow suppression is often a temporary side effect with a decrease in white blood cells and platelets up to 6–10 weeks. In this study, we aimed to examine hematological changes in patients who received RAI treatment for benign or malignant diseases of the thyroid.<p cla...

The obesity epidemic, which has persisted for more than 45 years, is now being faced concurrently with the coronavirus pandemic, with deadly effects. The complex changes caused by obesity, such as chronic inflammation, are known to be detrimental in patients with COVID-19. 33.2% of the Georgian population is obese (1). Therefore, we aimed to explore the synergistic effects between obesity and SARS-CoV-2. The objective of our study is to compare the presence of neutralizing ant...

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by progressive joint destruction and inflammatory activation and hyperproliferation of synoviocytes. We have previously reported a marked shift towards reduced local androgen metabolism in active RA, driven by changing expression of SRD5A1 and AKR1C3 within macrophages. In this study we examined the role of altered androgen metabolism and availability in the inflammatory function of both macr...