Endocrine Abstracts

Elevated macroprolactin level is one of the reason of misdiagnosis and mismanagement of hyperprolactinamia. About 10% of population have incidentalomas and it also can combine with increasing of prolactin (Prl).Three hundred and thirty patients with hyperprolactinemia (Prl>600 mU/l) were studied: 192 women and 138 men in age of 30 (25; 39) and 35 (29;46) years respectively. Clinical, biochemical and MRI methods were used. Prl, LH, FSH and Testosteron...

Factitious hypoglycaemia is characterised by high insulin levels but accompanied with low Proinsulin and C-peptide levels and a negative sulfonylurea screenWe present a 54-year-old woman who was initially diagnosed with type 2 diabetes in 2002 and by 2004, she was converted to insulin treatment due to poor tolerance to Metformin. She also had a previous history of Manic depressive psychosis and treated with lithium.In the months pr...

Iodine deficiency (ID) and ID disorders (IDD) are a global problem. ID elimination would significantly contribute to achieving at least 6 of the 8 millennium developmental goals.Aim: To adapt the Neonatal thyroid screening (N?S) based on TSH with a view to its applicability as a permanent indicator in monitoring the effect from the iodine prophylaxis of IDD in Bulgaria.Tasks: To study: 1) dependence of TSH on age after birth; 2) in...

Introduction: 18-hydroxycortisol (18-OHF) is known to be elevated in glucocorticoid remediable aldosteronism but there are few data relating to 18-OHF in the differential diagnosis of primary aldosteronism.Aim: We evaluated the usefulness of lying and standing 18-OHF in patients with primary aldosteronism in differentiating between aldosteronoma, bilateral adrenal hyperplasia (BAH) and normality.Methods: Patients (n=27) with...

Recently, the phenomenon of macroprolactinaemia has manifested itself into a great interest for physicians. This problem forces both physicians and patient to waste sizeable resources, and can lead to iatrogenic and unjustified emotional stress and further material losses. At the same time the problem of differential diagnostics of pseudoprolactinomas and true prolactinomas remains challenging. The purpose of the present study was to determine the clinic-analytical repercussio...

We report a falsely elevated blood spot thyrotrophin (TSH) concentration caused by a TSH-IgG complex. A routine blood spot screen returned a whole blood TSH of 213 mU/l from a one week-old neonate using the Wallac DELFIA method. Measurement in serum confirmed elevated TSH (826 mU/l, Roche Elecsys assay) but free thyroxine (17.2 pmol/l) was normal. The baby’s mother was clinically euthyroid but also showed discordant high serum TSH (287 mU/l) with normal free thyroxine (13...

The purpose: to study prevalence of classical forms of 21-hydroxylasae deficiency according to the results of neonatal screening on a congenital adrenal hyperplasia (CAH) in Tyumen, Russia.The analysis of neonatal screening on CAH results in Tyumen for the period of 2003–2004. For the period under research 20011 newborn have been tested on the 17-OHP level. Measurement of 17-hydroxyprogesterone in blood samples was done in the central laboratory by ...

Where screening for macroprolactin takes place, laboratories routinely rely on treatment of sera with polyethylene glycol (PEG) to distinguish macroprolactinaemia from true hyperprolactinaemia. However, PEG is incompatible with a number of common immunoassay platforms. The aim of this study was to assess the specificity and clinical utility of ultrafiltration as an alternative procedure for removal of bio-inactive prolactin IgG complexes such as macroprolactin from serum prior...

Where screening for macroprolactin takes place, laboratories routinely rely on treatment of sera with polyethylene glycol (PEG) to distinguish macroprolactinaemia from true hyperprolactinaemia. However, PEG causes significant interference in some immunoassays and furthermore leads to co-precipitation of a variable amount of monomeric prolactin in addition to macroprolactin in treated sera. The aim of this study was to assess the specificity and clinical utility of alternative ...

Analysis of sweat is well-established for the diagnosis of cystic fibrosis and for testing for drug abuse. Cortisol, cortisone and aldosterone were identified in sweat in 1948, and the presence of 11 beta hydoxysteroid dehydrogenase type 2 in the epidermis was reported in 1990. At present there are no studies of the diagnostic value of sweat cortisol measurement. We have evaluated the use of a sweat patch comprising a small 47 by 32 mm rectangle of filter paper secured by a wa...