Endocrine Abstracts

A large body of evidence suggests that in polycystic ovary syndrome (PCOS) there is a link between abdominal adiposity, visceral adiposity dysfunction and hyperandrogenism and this relationship could be bidirectional. However a well designed study of adipose tissue distribution reported no significant differences between PCOS and controls. Visceral adiposity index (VAI) is a recently reported marker of the cardiovascular risk, strongly correlated with visceral adipose tissue (...

The aim of the study was to evaluate the effects of hyperthyroidia on glycemic control in patients with diabetes mellitus.Research design and methods: We retrospectively evaluated the patients with diabetes and hyperthyroidism. We analysed clinical data, thyroid ultrasound exploration, laboratory analyses (glycosylated hemoglobin, free thyroxin FT4, triiodothyronine T3, thyroid stimulating hormone TSH).Results: We evaluated 48 pati...

Background: PCOS-associated increased metabolic risk may be selective, owing to its heterogeneous nature. Identification of high-risk individuals could enable better studies and prevention of complications.Aim: To characterize the metabolic risk, as metabolic syndrome (MetS), of specific PCOS subphenotypes.Subjects and methods: Romanian PCOS (Rotterdam criteria) and 64 controls, 18–35 years. PCOS subphenotypes were defined: i)...

Background: Hirsutism is a major feature of the polycystic ovary syndrome (PCOS) and the only accepted clinical sign of hyperandrogenism for its diagnosis, according to the androgen excess society (AES) recommendations. Previous studies demonstrated that hirsutism can be influenced by factors other than hyperandrogenism per se.Aim: To detect factors influencing hirsutism severity in PCOS.Patients and methods: Hundred and sev...

Introduction: The polycystic ovary syndrome (PCOS) and obesity are related, yet different complex diseases, with the same genes possibly playing different roles in each disease. INSIG2, an obesity-associated gene (by rs7566605 C/C genotype) is a good candidate for PCOS. Its genotypes were not associated with obesity in PCOS patients. To date, there are no published association studies of rs7566605 with PCOS itself.Aim: To perform a case-control associati...

Background: Androgen receptor (AR) activity is modulated by the length of CAG-repeat polymorphism in exon 1. Published data suggest association between CAG-repeat alleles and PCOS, but not all studies confirmed this finding.Aim: To test association of AR alleles with PCOS and clinical and biochemical signs of hyperandrogenism.Study design: Case–control association study, approved by the institutional ethical committee, of 137 ...

Congenital adrenal hyperplasia (CAH) comprises autosomal recessive disorders mainly due to defects in the 21-hydroxylase (CYP21) gene. We aimed to perform a genotype-phenotype analysis in Romanian patients with classical 21-hydroxylase deficiency.Patients and methods: We included 42 patients (13 males, 29 females, 19 with the salt wasting (SW) form, 29 with the simple virilizing (SV) form. Molecular analysis was performed by direct sequencing of PCR ampl...

Background: Higher anti-Müllerian hormone (AMH) values are associated with polycystic ovary syndrome (PCOS) and AMH is proposed as a marker of PCOS, however, the optimal diagnostic threshold is not yet defined.Aim: To study the significant correlations of AMH in PCOS and the accuracy and threshold of AMH for the PCOS diagnosis in Romania.Subjects and methods: Serum AMH, TT, LH, FSH, fasting glucose and insulin (Ins), HOMA-IR a...

Introduction: Zinc homeostasis is involved in numerous physiological and pathological conditions, ranging from type 1 and type 2 diabetes to memory impairment and cancer, and is determined by at least 28 genes, including 24 SLC (Solute Carrier) family members and 4 MTs (Metallothioneins). To explore the potential role of zinc homeostasis in MetS (metabolic syndrome) and IR (insulin resistance), we investigated 28...

Introduction: Zinc homeostasis is involved in numerous physiological and pathological conditions, ranging from type 1 and type 2 diabetes to memory impairment and cancer, and is determined by at least 28 genes, including 24 SLC (Solute Carrier) family members and 4 MTs (Metallothioneins). To explore the potential role of zinc homeostasis in MetS (metabolic syndrome) and IR (insulin resistance), we investigated 28...