Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

Published by BioScientifica

Page 2 of about 208 results

ea0038mte9 | (1) | SFEBES2015

Grossman Ashley

The term pituitary tumour usually implies an adenoma arising from anterior pituitary tissue, but in fact some 2–5% of ‘tumours’ in this region are not adenomas, and many of these arise from the para-sellar region or within the hypothalamus. One clue as to the non-adenomatous origin of such tumours is the presence of diabetes insipidus, which is almost never present with a primary pituitary adenoma. Some 1% of sellar masses are metastases, most often from the fre...
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ea0032s17.1 | Medical treatment of endocrine malignancies - an update | ECE2013

Pituitary carcinoma

Grossman Ashley

Pituitary tumours have recently been shown to have a prevalence of around one in a 1000, but the overwhelming majority of these are benign and readily treated. Nevertheless, while the initial therapy of the majority of non-secreting macroadenomas is transsphenoidal surgery, these have a high tendency to recur; recurrence cannot at present be predicted by any histopathological markers. Indeed, some 50% of such adenomas will recur over 10 years, although this recurrence rate is ...
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ea0031mte6 | (1) | SFEBES2013

Malignant phaeochromocytomas

Grossman Ashley

The great majority of phaeochromocytomas are benign, but some 10–15% are found to be malignant, the proportion being higher when they are extra-adrenal, paragangliomas. Malignant behaviour is hard to predict, and there are few histopathological features that are consistently of use. There are novel biochemical and molecular markers, but none has proven to be as yet especially reliable although elevated urinary methoxytyramine seems to be useful. At present, size is proba...
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ea0020s21.4 | Current problems in the management of pituitary tumours | ECE2009

Treatment options for aggressive pituitary tumors

Grossman Ashley

Pituitary tumours have recently been shown to have a prevalence of around one in a 1000, but the overwhelming majority of these are benign and readily treated. Nevertheless, while the initial therapy of the majority of non-secreting macroadenomas is transsphenoidal surgery, these have a tendency to recur even when apparently totally removed. Recurrence seems not to depend on dural invasion, and it cannot at present be predicted by any histopathological markers. Indeed, some 50...
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ea0008s25 | Neuroendocrine Tumours | SFE2004

THE MANAGEMENT OF NEUROENDOCRINE TUMOURS WITH RADIOACTIVE OCTREOTIDE

Grossman AB

Neuroendocrine tumours (NETs) are usually taken to include gastro-enterohepatic tumors including islet cell tumours and carcinoids; recent data suggest an overall incidence of around 30/million/year, but since such tumours usually present late curative surgery is rarely an option and chemotherapy of limited benefit. Radionuclide scintigraphy with somatostatin (SMS) analogues such as 111In-octreotide demonstrate the presence of SMS receptors in some 80%-90% of NETS; we have use...
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ea0007s5 | Clinical Endocrinology Trust Lecture | BES2004

Cycling into trouble

Grossman AB

Pituitary tumours are usually benign and present early due to hormonal hypersecretion: the mean size of corticotroph adenomas is only 100mm3. Furthermore, of the 6 essential stages in carcinogenesis (activation of oncogenes, loss of tumour suppressor genes, inhibition of apoptosis, immortalisation, vascular invasion and metastasis), probably only the first 3 are relevant to these tumours: this renders them a valuable paradigm for the earliest stages of oncogenesis. Menin and P...
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ea0059oc6.1 | Neuroendocrinology and Reproduction | SFEBES2018

A controlled cross-sectional study of bone microarchitecture in transgender individuals

Zajac Jeffrey D , Bretherton Ingrid , McFarlane Thomas , Spanos Cassandra , Grossmann Mathis , Cheung Ada S

Sex steroids have complex effects: testosterone predominantly regulates trabecular and estradiol, cortical bone1. Studies in transgender individuals use insensitive technology and report conflicting effects2. We hypothesized estradiol therapy will increase cortical volumetric bone mineral density (vBMD) in male-to-female (MtF) individuals and testosterone therapy will increase trabecular vBMD in female-to-male (FtM) individuals.Aims...
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ea0034p348 | Steroids | SFEBES2014

The effect of green tea extracts on steroidogenesis, proliferation and apoptosis in ovarian granulosa cells

Kadasi Attila , Maruniakova Nora , Kolesarova Adriana , Stochmalova Aneta , Alexa Richard , Grossmann Roland , Sirotkin Alexander V

The aim of our study was to examine the influence of green tea molecules on basic ovarian functions. For this purpose we have examine the effect of green tea extract, fraction of antioxidants (GTAO) and green tea fraction of polyphenols (GTPP) (at the doses 0, 1, 10, and 100 μg/ml) on proliferation, apoptosis, and steroidogenesis by cultured porcine ovarian granulosa cells. Markers of proliferation (PCNA) and apoptosis (bax) were detected by immunocytochemistry. Secretion...
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ea0028p262 | Pituitary | SFEBES2012

Quality of life in patients with non-functioning pituitary adenoma: the Oxford experience

Capatina Cristina , Christodoulides Constantinos , Fernandez Alberto , Grossmann Ashley , Wass John , Karavitaki Niki

Data on the quality of life (QoL) of patients with non-functioning pituitary adenoma (NFA) are sparse and conflicting. We have therefore evaluated the QoL in patients with NFAs followed-up in a tertiary UK referral centre and explored the impact of various factors. Three validated questionnaires (Short Form 36-SF36, Nottingham Health Profile-NHP and European Quality of Life Scale-EuroQoL) were offered to consecutive NFA subjects attending outpatient clinics over a 6-month peri...
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ea0026p119 | Female reproduction | ECE2011

The role of metabolic hormones ghrelin, leptin and obestatin in control of ovarian functions

Sirotkin Alexander , Meszarosova Monika , Grossmann Roland , Korzhenevskaja Marina , Benco Andrej , Pavlova Silvia

The recent original data concerning interrelationships between metabolic hormones (ghrelin, leptin, obestatin) and feeding, action of metabolic hormones on basic ovarian functions (proliferation, apoptosis, secretory activity, response to gonadotropins, oocyte maturation) and intracellular mechanisms of its action in different species (rabbit, pig, human, chicken) are reviewed. It was shown, that metabolic hormones ghrelin, leptin and obestatin can control proliferation, apopt...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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