Endocrine Abstracts

Occurence of mycotoxins in various food and feed commodities is a worldwide problem. T-2 toxin is one of the most toxic trichothecene mycotoxin, produced mainly by Fusarium species. Poultry belongs to very sensitive species which are very often explored to toxic effects of mycotoxins. The aim of our in vitro studies was to examine secretion activity of ovarian granulossa cells to produce progesterone P4 after T-2 toxin and its combinations with res...

In our in-vitro experiments we examined the involvement of insulin-like growth factor type II (IGF-II) in the control of ovarian function in domestic fowl, together with the intracellular mechanisms of IGF-II action. Fragments of ovarian follicles were cultured with and without IGF-II (1-100 ng/ml), blockers of protein kinase A (PAK, KT5820, 10 mg/ml), tyrosine kinase (TK, AG1024, 1mg/ml), mitogen-activated protein konase (MAPK, PD98059, 10 mg/ml), cyclin-dependent protein kin...

Introduction: Surgery is often the only treatment option that can effectively treat patients with insulinoma in MEN-1. However, the surgical intervention should be limited as surgery can not cure patients with MEN-1. It is, therefore, mandatory to correctly localize insulin secreting tumors from other neuroendocrine tumors.Materials and Methods: In this report we include 6 patients with proven endogenous hyperinsulinemic hypoglycemia and neuroglycopenia ...

Ghrelin is a novel growth hormone-releasing peptide, recently identified in the rat stomach as the endogenous ligand for the growth hormone secretagogue-receptor (GHS-R). Previously, regulation of GH release was thought to occur primarily via a phasic interaction between two hypothalamic neuropeptides, GHRH and somatostatin. It is now thought that ghrelin is an important third factor in the regulatory pathway. In addition to its GH-releasing activity ghrelin may have other act...

Lanreotide (LAN) Autogel, a new aqueous preparation of lanreotide acetate, was administered by deep sc injection every 4 weeks to patients with acromegaly (54 males, 53 females, mean age 53 plus/minus 1 year) who had previously been responsive to im SR LAN 30 mg microparticles. Patients who had been treated with at least 4 im injections of SR LAN 30 mg every 14 (49%), 10 (32%) or 7 days (20%) for at least 3 months and had a mean GH level <10 ng/ml, were switched to LAN Auto...

The majority of patients with Cushing’s syndrome are ACTH-dependent, but the diagnosis of ACTH-dependence, and then the differential diagnosis between Cushing’s disease and the ectopic ACTH syndrome, is dependent on the measurement of ACTH. In the mammalian adult anterior pituitary, POMC is cleaved into a variety of products including the ‘normal’ ACTH(1-39). In the pars intermedia (present in the human fetus and most mammals), ACTH is cleaved further by th...

The majority of patients with Cushing’s syndrome are ACTH-dependent, but the diagnosis of ACTH-dependence, and then the differential diagnosis between Cushing’s disease and the ectopic ACTH syndrome, is dependent on the measurement of ACTH. In the mammalian adult anterior pituitary, POMC is cleaved into a variety of products including the ‘normal’ ACTH(1-39). In the pars intermedia (present in the human fetus and most mammals), ACTH is cleaved further by th...

Background and aims: Immediate release somatostatin analogues (SAs) have routinely been administered to test tolerability prior to commencing long-acting SAs, though there is limited evidence to support this process. We aim to examine this practice at our centre.Methods: Patients who received SA therapy for a neuro endocrine tumours (NET) between December 2012 and December 2014 were identified. Records were used to identify; start date, duration of test-...

Aim: Audit was carried out in accordance with trust policy to review all adult patients initiated on Growth Hormone during the period April 2009 to April 2011 and primarly to evaluate efficacy and to ascertain if care is consistent with NICE guidelines.Method: Medical notes of all patients initiated on Growth Hormone during the stated period were retrieved. The cases we're audited against criteria 1, 2, 4, 5 and 6 as specified in NICE guideline TA 64, Ap...

Introduction: Ipilimumab (Yervoy, BMS) is a human monoclonal antibody increasingly used in oncology. It targets cytotoxic T lymphocytes antigen 4 (CTLA-4) promoting their proliferation and augmenting an anti-tumour response. It is licensed for the treatment of unresectable or metastatic melanoma and multiple clinical trials using this medication for other malignancies are ongoing. Ipilimumab related adverse reactions are mainly autoimmune and occur in 61% of patients, of which...