Endocrine Abstracts

Premature ovarian insufficiency (POI) is characterized by cessation of ovarian function before the age of 40. Variable clinical presentation often postpones the diagnosis. The aim of our study was to assess whether there is a typical menstrual cycles pattern in patients with POI. We have evaluated 101 women, age 36.7±5.78 y. FSH=78.81±37.43 IU/l, E2<50 pg/dl, with confirmed POI referred to our Clinic between 2014 and 2018. Menstrual cycles characteristics were de...

Introduction: It is presumed that hiccups are a vestigial reflex in mammals. They are rather common in healthy subjects. Persistent hiccups (lasting >48 h) are a serious clinical sign, and documented in a number of debilitating conditions. According to the available literature persistent hiccups in Addisonian crisis have been previously documented in only two patients.Case report: In July 2018, a 39 year old man checked into the ER complaining of nau...

It has been more than 70 years since the first adrenal incidentalomas (AI) were described. Most of these tumors are non-secreting, and are found in 4–7% of adult population. Patients with subclinical hypercortisolism (or autonomous cortisol secretion) (SH) are observed in 1–29% of patients with AIs. Evidence suggests that this condition may be associated with higher prevalence of diabetes, obesity, hypertension and osteoporosis.Between 1999 and...

It has been more than 70 years since the first adrenal incidentalomas (AI) were described. Most of these tumors are non-secreting, and are found in 4–7% of adult population. Patients with subclinical hypercortisolism (or autonomous cortisol secretion) (SH) are observed in 1–29% of patients with AIs. Evidence suggests that this condition may be associated with higher prevalence of diabetes, obesity, hypertension and osteoporosis.Between 1999 and...

Adrenal hemangioma is a rare adrenal tumour usually presented as incidental finding in asymptomatic patients. Due to its radiographic features sometimes it’s difficult to differentiate them from other malignant lesions. We present a 55-years-old men admitted to our department with adrenal incidentaloma size 5×4 cm confirmed by MSCT scan. Active phaeochromocythoma was excluded by normal urinary catecholamines. Endocrine evaluations revealed normal midnight cortisol, w...

Introduction: Turner’s syndrome (TS) or Ullrich-Turner’s syndrome is genetic condition that affects only females. It is characterized by typical physical features and complete or part absence of one of the X chromosomes. Women with TS have been reported to be at increased risk of autoimmune diseases as compared with other women. Idiopathic thrombocytopenic purpura (ITP), isolated low platelet count (thrombocytopenia) with normal bone marrow and the absence of other c...

Ganglioneuromas are benign sympathetic tissue tumors originating from neural crest cells. A 40-year-old female patient, was admitted to our department for endocrinological evaluation of incidentally discovered tumor of right adrenal gland. For about a year before admission she had a pain under the right costal arch. An ultrasound and computed tomography (CT) showed 2 ovoid cystical tumors of right adrenal (34 and 32 mm, respectively). Three months prior admission she had sever...

Introduction: Cushing’s syndrome (CS) results from inappropriate exposure to excessive glucocorticoids. Untreated, it has significant morbidity and mortality.Case report: A 38-year-old woman with a typical appearance of CS was admitted for further evaluation of hypercortisolism. The serum cortisol level was elevated without diurnal rhythm, with no adequate supression of cortisol after 1 mg dexamethasone suppresion test. Twenty-four-hour urinary free...

Involutive hypoandria (late onset hypogonadism) is characterized by decline in serum testosterone and increase of gonadotropins. Changes of hypothalamo-pituitary-testicular axis sensitivity are influenced by primary testicular changes and altered neuroendocrine regulation during aging. To evaluate age-related changes in gonadotroph and Leydig cell sensitivity two groups were formed: 1) 35 men, 51.8±3.2 years old, BMI=28.2±3.1 kg/m2; 2) 32 men, 63.2±6....

Adrenal incidentalomas are referred as clinically silent adrenal masses discovered incidentally during diagnostic testing or treatment for conditions not related to suspicion of adrenal disease. Certain percent of them are hormonally active and autonomous cortisol secretion is reported with increasing frequency. The aim of the study was to assess value of 1mg-DST in subclinical Cushing’s syndrome (CS) compared to the other forms of adrenal incidentalomas. We have evaluate...