Endocrine Abstracts

Introduction: Hyperostosis-hyperphosphataemia syndrome (HHS) is a rare autosomal recessive condition caused by inactivating mutations in the GALNT3 gene, characterised by elevated serum phosphate and 1,25(OH)2 vitamin D, increased urinary tubular reabsorption of phosphate and hyperostosis of long bones.Case report: A 15-year-old boy (weight+1.05 S.D.; height −0.1 S.D.) with consanguineous parents of...

The growing incidence of adrenal incidentaloma needs new methods of assessment of their function, especially for cases with subclinical hyperfunction. The bilateral adrenal incidentalomas in patients with subclinical Cushing syndrome (SCS) often need only unilateral surgery, but if their diameters and phenotypes are similar, coming to decision about side of adrenalectomy may be difficult. Another problem generate tumors suspected of subclinical aldosterone hypersecretion: the ...

Objective: In the Bethesda classification (BC), which is used in cytopathologic evaluation of thyroid nodules, follicular lesion of undetermined significance (FLUS) does not involve sufficient cellular atypia for follicular neoplasia or malignancy, while it doesn’t comprise the cytologic benign criteria. Therefore, there is no consensus for those nodules to follow-up and therapeutic approaches. In this study, we aimed to determine the ultrasonographic features and histopa...

The aim of the study was investigating of microvessels density (MD) and expression of vascular endothelial growth factor (VEGF) in adrenocortical tumors.Under investigation there were 23 adrenocortical tumors: adenomas – 13, ‘border’ tumors – 4, and carcinomas – 6. Immunohistochemical studied were carried out using monoclonal antibodies to both VEGF and endothelial marker CD34 (Dako). VEGF expression was estimated as a weak one (...

The mission of the European Reference Network on Rare Endocrine Conditions (Endo-ERN) is to reduce and ultimately abolish inaequalities in care for patients with rare endocrine conditions across Europe. Endo-ERN provides equality between paediatric and adult patients, and is supported by the European Society of Endocrinology and the European Society of Paediatric Endocrinology. In order to achieve Endo-ERN’s mission and accomplish the concrete objectives the first year wa...

Objectives: We aimed to evaluate the impact on postoperative voice outcome according to the degree of thyroidectomy skin flap.Methods: We randomly enrolled the patients underwent thyroidectomy into conventional thyroidectomy group (group 1) or minimally skin elevated thyroidectomy group (group 2). Skin flap was elevated to thyroid notch superiorly in group 1 and to superior border of cricoid cartilage superiorly in group 2. Inferior border of skin flap w...

Introduction: Trans-axillary surgery is an emerging technique for cervical approach with fantastic cosmetic result. With more than 50 cases treated by our group, we developed our technique with specific safe methodologies.Aims: To present step-by-step technique of trans-axillary endoscopic thyroidectomy.Material and methods: This is a video surgery that uses three trocars and a harmonic scalpel for dissection and ligation. Incision...

Introduction: Cells with stem-like properties have been reported in benign and malignant thyroid diseases, and can be propagated by culturing them as non-adherent spheres.Design: Aim of the present study was to widely characterize the stem-like cells in tumor and normal thyroid tissues and in the corresponding in vitro-cultured thyrospheres, and to investigate in vivo the proangiogenic potential of thyrospheres in a zebrafish model....

Subclinical atherosclerosis is frequently present in women with polycystic ovary syndrome (PCOS). Metformin and liraglutide both improve metabolic control in PCOS, however they might exert different anti-atherosclerotic effects. We investigated the impact of these medications on the subclinical atherosclerotic changes of the arterial wall in PCOS patients.Results: 25 patients on metformin and 40 patients on liraglutide completed the study. Metformin impr...

Aim: To evaluate serum (SMK) and nodular (NMK) midkine levels in thyroid nodules and explore its relevance to ultrasound feature/pathological results.Methods: A total of 80 patients (56 women, 24 men) with thyroid nodules were included in this prospective study. Hemograms, thyroid function tests, fine needle aspiration biopsies, ultrasonographic evaluation were routinely made. In addition, levels of SMK and NMK were measured. Any possible correlations be...