Endocrine Abstracts

Introduction: The majority of adrenal neoplasms are benign while adrenocortical carcinomas (ACC) are rare with poor prognosis. Previous studies indicated that estrogens play important role in the etiology and progression of adrenocortical tumors. Estrogens exert genomic activities trough the estrogen-receptor (ER) subtypes α and β, while the non-genomic effects are mediated by membrane-bound-G-protein-coupled-ER-30 (GPR30). Although estrogens induce cancer cell ...

Introduction: The majority of adrenal neoplasms are benign while adrenocortical carcinomas (ACC) are rare with poor prognosis. Previous studies indicated that estrogens play important role in the etiology and progression of adrenocortical tumors. Estrogens exert genomic activities trough the estrogen-receptor (ER) subtypes α and β, while the non-genomic effects are mediated by membrane-bound-G-protein-coupled-ER-30 (GPR30). Although estrogens induce cancer cell ...

Introduction: Hypercortisolaemia is characterised by an increased risk of cardiovascular disease (CVD), either through a direct action on the myocardium or by affecting traditional cardiovascular risk factors. The electrocardiogram (ECG) is the initial examination to assess the structural and functional characteristics of the myocardium.Aim of the study: To investigate whether the metabolic and cardiovascular features of Cushing’s disease (CD) are a...

Background: Non-alcoholic fatty liver disease (NAFLD) is a very common liver disorder associated with insulin resistance and the metabolic syndrome. Insulin resistance is also a prominent feature even in lean women with the polycystic ovarian syndrome (PCOS). The objective of this study was to identify the presence of NAFLD in young lean women with PCOS.Methods: Fifteen women with PCOS and 10 controls participated in the study.Mean...

Background: Low-grade systemic chronic inflammation has been recognized in diabetes. The purpose of this study was the assessment of proinflammatory cytokines secretion profile in long-standing diabetes along with the presence of systemic inflammation.Methods: Twenty patients with type 1 (T1DM: 7 women, age (±S.E.M.): 30.90±1.93 years, duration of disease: 142.47±28.34 months) and 21 patients with type 2 diabetes mellitus T2...

Background: Cyclical Cushing’s syndrome has been considered to be a rare clinical entity, characterised by periodic increases in cortisol levels followed by regression of the Cushing’s syndrome. The cycles of hypercortisolism may occur before the establishment of the diagnosis, rendering actual diagnosis difficult, or may occur after inadequate or ineffective treatment and affect disease management. The aim of this study was to investigate the prevalence of cyclicity...

Introduction: Treatment with sodium glucose co-transporter2(SGLT2) inhibitors was found to reduce the incidence of cardiovascular events in diabetic patients.Herein, we investigated the effects of long-term treatment with canagliflozin on atherosclerosis development in the aorta of Apolipoprotein E knockout (Apo-E(−/−)) mice as well as on biochemical and immunohistochemical markers related to atherosclerosis.Methods: At 4 weeks of ...

Background: The aim of the study was to assess the clinical features of gastric neuroendocrine neoplasms type 1 (GNEN1).Methods: We have analyzed the clinical data of the first 73 patients with GNEN1 from our registry.Results: The mean age(±S.D.) of the patients (51 (68.9%) females) and the mean follow-up were 55±12.3 years and 28.8±42.2months, respectively. All patients had sporadic tumors and all wer...

Introduction: Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease in the western world affecting 5-33% of the general population. Polycystic ovarian syndrome (PCOS) is a common endocrinopathy affecting 6-10% of women of reproductive age. In both conditions, insulin resistance (IR) seems to be a common pathogenetic mechanism.Objective: To investigate the presence of NAFLD in lean and obese women with and without PCOS ...

BackgroundRecent data have shown the anti-apoptotic effect of Chchd2 mitochondrial protein through the Bcl-2/Bax pathway in various cancers. Bax is regulated primarily by proteins-members of Bcl-2 family and mainly the Bcl-2 protein, which has been found to prevent Bax from accumulating in mitochondria. In response to apoptotic stimuli, Chchd2 decreases and loses its mitochondria localization accompanying by decreased Bcl-2/Bax interaction and increased ...