Endocrine Abstracts

In the reproductive age, it is well-known that males are more sensitive to cardiovascular ischemic disease than females. In our study, we investigated the role of heme-oxigenase synthase (HO), which produce endogenous vascular protective carbon monoxide, in the development of sexual dimorphism in rats. We found that HO synthase enzyme activity, and the expression its HO-1 and HO-2 isoenzyme were increased in female rat aorta and left heart ventricle compared to males. Moreover...

Aims: The prevalence of type 2 diabetes due to insulin resistance is increasing in puberty. Authors have investigated whether body weight excess arises only from increased fat content of the body. Different anthropometrical data were also analysed if they are able to predict degree of insulin resistance.Materials and methods: 108 obese children (50 female, 58 male, Tanner st-s1-5, mean age 12.06 years, mean BMI: 30.97 kg/m2) with positive fami...

Long-term follow-up of differentiated thyroid cancer (DTC) patients requires yearly measurements of serum thyroglobulin (Tg) levels is endogenous (4 weeks off-thyroxin) or exogenous (human recombinant TSH injection) high TSH state. Subclinical hyperthyroidism is maintained in the patients throughout the rest of the year. We examined the endothelial function, hemostasis factors and metabolic parameters in short-term iatrogenic hypothyroidism (HO) and in subclinical hyperthyroid...

Drinking water is the major natural source of iodine in many European countries. In the present study, we examined possible sites of iodine loss during the usual water purification process. Water samples from 6 sites during the technological process were taken and analyzed for iodine content. Under laboratory circumstances, prepared iodine in water solution has been used as a model to test the effect of the presence of chlorine. Samples from the purification sites revealed tha...

The optimal treatment of hyperthyroidism in Graves’ disease is still an unresolved question. Hyperthyroidism recurs in 50% of patients after discontinuation of antithyroid therapy. In this retrospective study, Graves’ patients investigated in the endocrine unit of Pecs University between December 2004 and October 2006 were enrolled (68 women, 22 men, age 47 (15–79) years). Antithyroid drug therapy was applied for a minimum of one year and the treatment was withd...

The succinate dehydrogenase (SDH) enzyme complex consisting of four subunits (SDHA, SDHB, SDHC and SDHD) has a dual function in the process of mitochondrial energy generation. It converts succinate to fumarate as part of the TCA cycle and also transfers electrons to ubiquinone as part of the electron transport chain. Mutation in any subunit of the enzyme complex increases the risk for the development of neuroendocrine tumors including paraganglioma (PGL) and pheochromocytoma (...

Background: Hypothyroidism is one of the most frequent conditions in endocrinology. Despite of that fact, indications for treatment differ among specialists in Spain.Aims: To identify attitudes of Spanish endocrinologists in the use of levothyroxine (LT4) therapy and the management of hypothyroidism.Methods: The members of the Sociedad Española de Endocrinología y Nutrición (Spanish Society of Endocrinology ...

Introduction: The autoimmune polyglandular syndrome is a complex, heterogeneous disease in which autoimmune diseases of endocrine and non-endocrine organs can occur. There are 4 subgroups: the early-onset APS I develops due to the mutation of the gene AIRE and characterized by the presence of Addison’s disease (AD), mucocutan candidiasis and hypoparathyroidism; the APS II is defined by the appearance of AD and autoimmune thyroid diseases (AITDs) and/or diabetes mellitus; ...

Introduction: Both cortisol and vasopressin are stress hormones. Earlier, our group demonstrated that serum concentrations of free cortisol at admissions to the Intensive Care Unit (ICU) were independent predictors of survival in critically ill patients. Other investigators have demonstrated that serum copeptin, a surrogate marker of vasopressin may also be a predictive factor in this patient population. The aim of our present study was to compare the prognostic roles of serum...

Introduction: The autoimmune polyglandular syndrome (APS) is a complex, heterogeneous condition in which autoimmune diseases (AIs) of endocrine and non-endocrine organs can occur. There are four subgroups. The majority of patients are categorized as having APS II or APS III. In APS II, patients have Addison’s disease (AD) and autoimmune thyroid diseases (AITDs) or type I. diabetes mellitus (T1DM), while in the APS III, AITDs are combined with other autoimmune illnesses ex...