Endocrine Abstracts

IL17 proinflammatory cytokine through T cell activation has prominent bone-wasting effect. Our previous results highlighted the role of IL17 in postmenopausal osteoporosis. To demonstrate the HLA allele association with the increased IL17 levels in postmenopausal osteoporosis was the object of the study.HLA class I and II alleles were measured in 64 postmenopausal women (in four subgroups: with low IL17 (1, 3) and high (>3.04 pmol/l) IL17 levels (2, ...

The total 25-hydoxy-vitamin-D (t25OHD) level can be assessed by various methods and reflects vitamin D intake. Results are influenced by the serum variables affected by dialyses.Aims: To examine t25OHD and bioavailable vitamin D (b25OHD) by two methods in patients on peritoneal-(PD) and hemodialysis (HD).Methods: We studied 37 HD (64±15 years) and 36 PD (63±18 years) patients. The t25OHD was assessed by chemiluminescence ...

Introduction: Hypophysitis is an inflammatory disease of the pituitary gland that may mimic pituitary tumors clinically and radiologically. Primary hypophysitis has traditionnaly been classified as lymphocytic (LH), granulomatous (GH), and xanthomatous (XH).Case description: We report on a case of a xanthomatous hypophysitis initially diagnosed as pituitary adenoma. A 23-year-old men suffered from typical cluster type headache. Two years after the first ...

Introduction: Hyperthyroidism has been suggested to adversely affect cognitive function. However, this association could also be caused by genetic and environmental factors affecting both the development of hyperthyroidism and cognitive functioning. By investigating cognitive function within twin pairs discordant for hyperthyroidism, this potential confounding can be minimized. The aim of this study was to examine if hyperthyroidism is associated with long-term cognitive dysfu...

Background: Hyperthyroidism has been associated with increased all-cause mortality. Whether the underlying cause of hyperthyroidism influences this association is unclear. Our hypothesis was that Graves’ disease (GD) and toxic nodular goiter (TNG) differ with respect to mortality risk and cause of death.Methods: An observational cohort study, using record-linkage data from nation-wide Danish health registers. 1.291 and 861 subjects with GD and TNG, ...

Background: Hypothyroidism has been linked with an increased risk of morbidity such as cardiovascular disease and diabetes mellitus. However, it is unknown whether the burden of morbidity is present before or after the diagnosis of hypothyroidism.Aim: Evaluate the temporality and type of morbidity in hypothyroid patients.Methods: Observational cohort study. Based on record-linking between official Danish health registers 2822 subje...

Introduction: Beside remnant ablation and treatment of known metastases, radioiodine treatment of differentiated thyroid cancer is suitable for the discovery of unknown or suspected metastatic disease. In this study, the clinical utility of SPECT/CT, a hybrid imaging method was evaluated after radioiodine therapy.Patients and methods: Between July 2007 and March 2012, 260 investigations were performed at 188 patients. Male:female ratio was 47:141. Every ...

Introduction: Obesity caused health problems are increasing. Metabolic syndrome including obesity with insulin resistance, hypertension, and high blood lipid levels increases the risks of cardiovascular and inflammatory diseases. Many studies have reported that heme oxygenase (HO) inducers reduce insulin resistance and severity of inflammatory bowel disease. We investigate the anti-inflammatory effect, one among many positive effects, of regular recreational physical activity ...

Introduction: Physical inactivity, i.e. sedentary life style increases circulatory disease risk. Carbon monoxide and nitric oxide produced by the heme oxygenase (HO) and by the constitutive nitric oxide synthase (cNOS) protect circulation. In contrast, the enhanced level of the matrix metalloproteinase (MMP) augments cardiovascular risks. We examined the actions of recreational physical exercise on the expression of these enzyme systems in conjunction with cardiovascular prote...

Introduction: Selective oestrogen receptor modulators function as oestrogen receptor antagonist in the breast and gonads, while they have agonistic effects on the bone and the cardiovascular system. It is also known that endogenously produced carbon monoxide by the heme-oxigenase (HO) enzyme exerts beneficial actions in cardiovascular protection.Design: Intact females, ovariectomized (OVX), raloxifene or oestrogen treated OVX Wistar rats were used. We st...