Endocrine Abstracts

Background: Peri-operative guidelines (POG) published early 2020, were followed by the NHS National Patient Safety Alert (NatPSA) and launch of the NHS Steroid Emergency Card (SEC) in Aug 2020. The NatPSA was sent to all NHS health and care providers. This survey was undertaken to assess the implementation and impact of both.Methods: A pilot survey was undertaken at Endocrine Nurse Update 2022 and amended survey emailed ...

Introduction: Childhood obesity is associated with various complications and medical treatment options are limited. Liraglutide, a GLP-1 receptor agonist, has shown improvement in body mass index (BMI) in clinical trials and has been licensed for clinical use in adolescents >12 years of age. The aim of our study is to evaluate the effect of liraglutide treatment on cardiometabolic variables, quality-of-life (QoL) and satiety levels in adolescents with seve...

In January 2023 a Medicines Supply Notification (MSN) was issued by the Department of Health and Social Care (DHSC) regarding a shortage of Norditropin (somatropin) products. The MSN recommended that all patients on Norditropin FlexPro 10mg pens and NordiFlex pens (all strengths) be changed to Omnitrope SurePal. Each patient affected by the shortage needed to be informed of the issue, a new prescription issued, and training provided on the new device. Affected patients were id...

Introduction: Multiple endocrine neoplasia type 1(MEN1) is an autosomal dominant disorder resulting from pathogenic variant in tumour suppressor gene MEN1 and is characterized by parathyroid, pancreatic islet and anterior pituitary tumours. We describe an unusual case of MEN1 patient who presented with pancreatic neuroendocrine neoplasms (pNEN) prior to onset of puberty.Case report: A Caucasian boy with a diagnosis of ma...

Temple syndrome is due to loss of methylation at 14q32. Features are prematurity, low birth weight, hypotonia, feeding difficulties, short stature and early puberty, as well as small hands and feet, mild learning disability and variable obesity. We report monozygotic twins with Temple syndrome. Twin1 was born at 31+2 weeks with mild SGA (1120g, <10th centile), head circumference 27 cm, undescended testes, severe hypotonia and laryngomalacia. He developed camptod...

Introduction: Childhood obesity is associated with complications, such as impaired glucose tolerance and type 2 diabetes mellitus. The gold standard investigation for diagnosing glycaemic alterations is an oral glucose tolerance test (OGTT). Continuous glucose monitors (CGM) are routinely used in the management of children and young people (CYP) with type 1 diabetes mellitus. The aim of our study is to investigate whether CGM is more effective in identifying g...

Introduction: Socio-economic factors have a huge impact on children and young people’s (CYP) overall health status. The rates of childhood overweight and obesity continue to rise and the CYP from areas with higher social deprivation are adversely affected with higher rates of obesity. We report the link between socio-economic deprivation and complications from excess weight (CEW) in the CYP being managed in a tier 3 multi-disciplinary (MDT) weight managem...

Background: Pancreatic neuroendocrine tumours (pNETs) are commonly reported in patients with MEN1. The estimated incidence is reported as 40–80% of adults with MEN1 and pNETs are frequently multifocal. Guidelines recommend that CT, MRI and endoscopic ultrasound (EUS) can be used for detection and surveillance of pNETs in MEN1. MRI has been the most commonly used modality, but EUS may be more sensitive in detecting pNETs.Objective: To compare the sen...

Background: There is no consensus on the optimal timing of surgery for primary hyperparathyroidism (PHPT) in MEN1. Experienced centres recommend subtotal or total parathyroid surgery with three and a half gland surgery along with thymic removal as a favoured procedure; but long-term outcomes have rarely been reported.Objective: To investigate the indications and outcomes for surgery in patients with PHPT in MEN1Methods: Review of c...

Background: Prior to COVID-19, HbA1C was performed in clinic as a point of care test. As a service development project driven by the changes to our service from COVID-19 we offered either a hospital drive through point of care HbA1C test or the validated VAMS collection method to obtain HbA1C at home.Objective: Research ethics approval was obtained to assess patient/carer acceptability of these collection methods.Methods: Drive thr...