Endocrine Abstracts

Introduction: Childhood obesity is a severe public health concern. Various complications are recognised in adults, but the data remains limited in the paediatric population. Therefore, the aim of this study is to investigate the complications observed in children and young people (CYP) with obesity.Method: Retrospective data collection from 125 CYP aged between 0 and 18 years with a body mass index (BMI) standard deviation score (SDS) of two or more abov...

Introduction: Recent experience of C-peptide testing in adults with longstanding diabetes has revealed misdiagnosis of monogenic diabetes as either type 1 or type 2 with important implications for quality of life and healthcare costs. Correct diagnosis earlier in life may be possible with the use of routine antibody testing at diagnosis and c-peptide measurement 3 years after initial diagnosis. Negative or low titres for all 3 antibodies suggest non-type 1 diabetes. Persistenc...

Background: Management of diabetes in patients with End Stage Renal Failure (ESRF) is complex, requiring intervention from multiple disciplines. The Joint British Diabetes Societies and Renal Association published the first ever guidelines for the management of patients with diabetes undergoing haemodialysis for ESRF in 2017.Aims and objectives: Assess Current Care Pathways of all patients with Diabetes undergoing Haemodialysis in Cork University Hospita...

Introduction: Foot disease in diabetes is associated with significant morbidity and mortality. Diabetic foot disease requires complex care with input from a range of healthcare professionals. Scottish Intercollegiate Guidelines Network guideline 116 recommends that all patients with diabetes and foot ulceration are seen at a multidisciplinary foot clinic. Our aim was to assess the impact on patient outcomes of introducing a multidisciplinary foot clinic within NHS Fife.<p ...

Introduction: I report the case of a premature neonate who developed a transient hyperphosphatemia at 1 month of age with associated hyperuremia, hypercreatininemia and hyperparathyroidism.Case report: This baby girl was born by emergency caesarean section for maternal APH at 27+6 weeks. She had an uneventful neonatal period with minimal ventilation. She was treated with ibuprofen, amilorone and frusemide for a PDA with associated heart failure. Her ente...

The management of children and young people (CYP) with diabetes is forever evolving, with tools and management strategies becoming much more intense. Year on year this has led to an overwhelming burden of educating schools when providing training for over 300 patients with type 1, type 2 and rarer types of diabetes. Children spend on average 1,267.5 hours per year in school – it is essential children’s diabetes management is optimised during this time, and health car...

Introduction: Epidemiological evidence suggests that a poor diet during pregnancy leads to offspring with higher risk of chronic diseases in adulthood. Our previous work in sheep showed that mild protein-energy malnutrition in early gestation results in decreased insulin signalling in the liver, and changes in vascular endothelial growth factor (VEGF) in the kidney. The current study explored whether these changes are generalised phenomena, or organ-specific.<p class="abst...

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Cushing’s syndrome and obesity share clinical similarities. Here we present a 31-year-old lady with type 2 diabetes, renal failure, polycystic ovarian syndrome, depression, hirsutism and morbid obesity, whose abnormal phenotype and biochemistry normalised with weight loss.She was admitted with a history of recent onset recurrent hypoglycaemia and poor mobility. A detailed history revealed increase in weight over a 10 year period associated with irre...

Objective: We sought to assess the knowledge of adrenal insufficiency among undergraduate healthcare students and pharmacy staff.Methods: We undertook a cross-sectional UK-wide survey of final year undergraduate student knowledge of AI before and after an online educational intervention. Universities were recruited through the Council of Medical Schools, Council of Pharmacy and Dean of Health Council, whereby surveys wer...