Endocrine Abstracts

Introduction: The quantitative ultrasound (QUS) is an useful tool in the evaluation of the fragility fracture risk.Aim and study design: We performed the QUS fragility fracture risk groups (valided by the golden standard DXA) by a unifactorial analyze including the bone markers.Method: The cut offs used were: SI≤59U (high risk), SI≥83U (low risk), and medium risk with SI between 59 and 83U. The QUS analyze was performed...

Background: Cushing’s syndrome (CS) is associated with a hypercoagulable state and an increased risk for acute coronary syndromes, stroke, and deep vein thrombosis (DVT).Aim: To assess the prevalence of thrombotic events in a series of patients with CS.Patients and methods: Notes of 113 patients with CS were retrospectively reviewed.Results: Instable angina was diagnosed in ten women, aged 52.1±12.2...

Background: Endocrine hypertension accounts for around 3% of the secondary forms of hypertension and screening of young hypertensive patients for secondary causes is mandatory.Aim: To present difficulties in endocrine assessment of arterial hypertension in people younger than 40 years.Patients and methods: Twenty-two patients (15 M/7 F), aged 27.1±7.7 years (range:16-40 years), with systemic hypertension (systolic blood pressu...

The structural and functional effects upon arterial vessels of GH and IGF1, chronically elevated in active acromegaly, are risk factors for premature atherosclerosis, but current therapies can normalize GH and IGF1 production.Aims: To evaluate if carotid wall alterations in acromegaly are reversible after disease control.Material and methods: Fifteen patients with controlled acromegaly (CA) after multimodal therapy (45.5±</...

AbstractThyroid angiosarcoma is an aggressive and very rare type of thyroid malignancy originally diagnosed in iodine-deficient areas. The prognosis is poor and in most cases surgery proved to be inefficient. The fine needle aspiration biopsy (FNAB) and histology can rarely differentiate angiosarcoma from anaplastic carcinoma, and the final diagnosis is based on immunopositivity for vascular markers and absence of epithelial markers. We present he...

Introduction: Osteogenesis Imperfecta (O.I.) is a genetic disorder commonly known as brittle bone disease. The majority of people with O.I. have a mutation in one of two genes, COL 1A1 or COL 1A2, that encode type I collagen. In most families, O.I. is inherited in an autosomal dominant pattern. Dual Energy X-ray Absorptiometry - bone mineral density (DXA-BMD) test provides information about bone quantity, not quality. The bisphosphonates - treatment can minimizing fractures by...

Introduction: Even the differentiated thyroid neoplasm have good prognostic, there are some particular cases that become very aggressive in short time, with poor management.Aim: We report a female case diagnosed with invasive papillary thyroid carcinoma.Case report: Seventy-three-year old female was diagnosed at age of 71 with a right lobe thyroid nodule (of almost 6 cm). At that moment the computed tomography (CT) of the cervical ...

Background: Thermoregulatory disorders after neurosurgery of craniopharingyomas were seldom reported.Aim: To present the difficulties of etiologic diagnosis and treatment of a persistent febrile syndrome in a patient with surgically removed craniopharyngioma.Patient and methods: A 34 years old man with a giant craniopharyngioma situated in the basal-anterior part of the third ventricle is reported. Anterior pituitary hormones were ...

Background: The Phase III PAOLA study assessed the efficacy and safety of pasireotide LAR versus continued treatment with octreotide LAR or lanreotide Autogel in patients with uncontrolled acromegaly. The current analysis investigated overall baseline characteristics and response rates to pasireotide according to co-morbidities.Methods: Patients were classified into five groups of co-morbidities related to acromegaly: glucose- (n=104), endocrine...

Introduction: Patients with untreated acromegaly have a reduced survival, mostly due to vascular disease. Recent studies claim an improvement of survival in the last years.Aims: To assess mortality ratio and to identify prognostic factors associated with reduced survival in acromegaly.Methods: Three hundred and twenty-seven patients (207 F/110 M, mean age 48.1±0.7 years, (range 18–81.42)) with acromegaly admitted in a sin...