Endocrine Abstracts

Introduction: There are high levels of anterior pituitary hormones in the cerebrospinal fluid (CSF), i.e. beyond the blood–brain barrier, in many patients with pituitary tumors.Aim: To assess the influence of CSF pituitary hormones on brain functions reflected by sleep architecture and sleep apnea.Method: Twenty-nine patients (17 women, 12 men) with pituitary adenomas (20 acromegaly, 5 nonfunctioning pituitary adenomas, 4 prol...

In acromegalic patients growth hormone (GH) excess induces insulin resistance but whether this is sufficient, in the face of normal insulin secretion, for pre-diabetes (impaired fasting glucose (IFG) and impaired glucose tolerance (IGT)) to occur is a matter of debate.Aim: To assess the relative role of insulin resistance and insulin secretion in the pre-diabetes of acromegaly.Methods: One hundred and twenty-four patients with acro...

Lanreotide has long been used in the therapy of GH secreting pituitary adenomas and other somatostatin receptor positive neuroendocrine tumors.Aims: To determine the impact on glucose metabolism of the 6 months of lanreotide therapy, beside of the antisecretory and antiproliferative effects.Patients and methods: Seven patients with active acromegaly treated with lanreotide, admitted in the Department of Neuroendocrinology, Institut...

Our initial studies suggested that plurihormonal cells are constantly found in early embryonic stages of human pituitary but are very rare later.Aim: A quantitative evaluation and morphological characterization of these plurihormonal cells.Methods: Pituitaries from therapeutically aborted human fetuses of 8–24 weeks, gestational age were fixed (with ethical permission) by immersion in 4% buffered formaldehyde. One-μm-thic...

Aim: To assess cumulative incidence and risk factors for amiodarone-induced thyroid dysfunction (AITD) in a large cohort of Romanian subjects.Subjects and methods: One hundred and forty-four patients (59 M/85 F), mean age 61.4±0.9 years, treated 2.4±0.2 years with amiodarone were assessed for TSH, TT3, TT4 (immunoradiometric assays) and FT4, TPO Ab (microenzymatic immunoassays). Thirty-three patients were reside...

Background: Acute right ventricular dysfunction (RVD) on echocardiography (ECHO) is critical for risk stratification in pulmonary embolism (PE). Plasma BNP, a consecrated marker of left ventricular dysfunction, could represent a valuable biomarker of RVD in PE.Aim and objective: Assessment of plasma BNP levels in patients with PE in relationship with right ventricular (RV) function evaluated by ECHO.Methods: Prospective study of 70...

Aim: To set up, in acromegaly without diabetes mellitus, a correlation between the disease activity in GH-secreting adenoma (AA) - assessed by minimum GH serum level during an oral glucose tolerance test (OGTT) - and severity of insulin resistance (IR), assessed by HOMA-IR index.Methods: 75 out of 88 consecutive patients with acromegaly hospitalized in our department were included in this study. 13 patients proved to have diabetes mellitus and were exclu...

Until recently primary aldosteronism /PA/ was thought to be rare, accounting for no more than 0.05–2% of the hypertensive patients. Studies published in the last decade demonstrate that primary hyperaldosteronism is a much more common cause of secondary hypertension than was previously thought, accounting for as many as 5% to 25% of hypertensives in some series. For the present, there are no data concerning the prevalence of PA in Bulgaria which determined the realization...

Context: Diabetes mellitus (DM) is common among hospitalized patents. An inpatient diabetes management service (IDMS) has been implemented to provide better glycemic control. The impact on length of stay (LOS) and 30-day readmission rates is unknown.Objective: We retrospectively analyzed LOS and 30-day readmission rate of patients with known DM admitted to a 240-bed community hospital in suburban Maryland between January 2016 and May 2017.<p class="a...

Background: Almost all patients with Multiple Endocrine Neoplasia, type 2A (MEN 2A) have MTC. C-cell hyperplasia develops early in life and can be viewed as the precursor lesion for MTC. Children with MEN2A who have a total early thyroidectomy have an excellent chance of remaining disease-free.Objectives: To follow-up the children with RET mutation in a family with MEN2A.Methods: We report a family with MEN2A in which the first pat...