Endocrine Abstracts

Retinopathy is one of the more serious complications of type 1 diabetes. There is emerging knowledge re the development of retinopathy in childhod diabetes. We studied the clinical profiles of children with retinopathy in an industrial town in Northern England. The current clinic size is 160. 42 patients were identied from clinic records as having retinopathy. Formal screening is offered to all patients from age 12. The age range was 11–20 years; median age 16. 55% were f...

Introduction: Hyponatraemia is associated with increased inpatient mortality, but there is debate about whether hyponatraemia per se contributes to mortality or is merely an epiphenomenon of severe illness.Methods: This retrospective review of medical records included all inpatients with serum sodium (sNa)≤128 mmol/l who died at a teaching hospital over a 3-month period. The aim of this study was to examine the clinical course and the pote...

Introduction: Although skin tag is associated with diabetes mellitus, no data in the literature show that the presence of skin tag is associated with diabetic macro and microangiopathy. The purpose of this study was to investigate frequency of hypertension, dyslipidemia, obesity, macro and micro angiopathy in type 2 diabetic patients with and without skin tag.Methods/Design: We evaluated 99 (40 female and 59 male) type 2 diabetic patients. All patients w...

The hypothalamic–pituitary unit is a particularly radiosensitive region in the central nervous system. As a consequence, hypopituitarism commonly develops after radiation treatments for sellar and parasellar neoplasms, extrasellar brain tumours. Increasing tumour-related survival rates provide an expanding population at risk of developing hypopituitarism. The severity of hypopituitarism is related to the radiation doses given while whole body irradiation regimens to a dos...

Introduction: Ramadan fasting may alter fuel metabolism and energy expenditure by inducing changes in the meal timing, sleep–wake patterns and physical activity. It could affect blood glucose through disrupting energy balance. Evaluation of resting energy expenditure (REE) could help to recommend best nutrition advices to diabetics for maintaining acceptable metabolic control.Methods: Thirteen type 2 diabetics who were fasted in Ramadan were compare...

In these times of restricted funding, it becomes crucially important that you position yourself to be the only possible candidate for future employment in a postdoctoral position or any other career path that you chose. The time to do this is during your PhD and MD studies and during your first postdoc. There are no hard and fast rules about how you do this, but some pointers may help. First, you must have a passion for research if this is what you want to do. If this is a job...

Ghrelin is stored alongside glucagon in developing islet, although in a discrete cellular compartment, the pancreatic ε-cell. However, recent observations have shown a subpopulation of ghrelin/glucagon-double-positive cells in developing pancreas. The aim of the present study was to examine the developmental patterns of ghrelin- and glucagon-immunoreactive (ir) cells expression and possible co-localization of these hormones during human pancreas development. For this purp...

Chronic autoimmune thyroiditis and Graves’ disease (GD) are two forms of autoimmune thyroid disease (AITD).The association of GD or other thyrotoxic forms of autoimmune thyroiditis with one or several toxic nodules is the Marine – Lenhart syndrome (SML). It is a rare pathology with prevalence between 2.7 and 4.1%. Its physiopathology remains complicated and misunderstood, incriminating antithyroidian auto-antibodies such as TSH re...

Prolactin (PRL) is a peptide hormone produced by the anterior pituitary gland and it is commonly known for its lactogenic and mammotrophic effects. In humans and primates, prolactin is also expressed in extra-pituitary sites where it is associated with numerous biological functions, but its spectrum of expression varies in different species.Hyperprolactinemia-induced osteoporosis is believed to be mediated by hypogonadism, but the expression of the prola...

Background – objective: Medullary thyroid carcinoma and hyperparathyroidism coexistence is well described in the literature. On the other hand, data regarding the coexistence of non-medullary thyroid cancer and hyperparathyroidism are scarce. The aim of this study was to evaluate the occurrence of such coexistence.Methods: This is a retrospective study of all patients with primary or secondary hyperparathyroidism who underwent parathyroidectomy in o...