Endocrine Abstracts

Introduction: EAS is an endocrine emergency requiring emergency diagnosis/treatment. Bronchial carcinoid is known to cause EAS and carcinoid syndrome (without liver involvement).Clinical features: 58-year-old lady with COPD and fibromyalgia referred as 2WW pathway with abdominal pain, diarrhoea, and weight loss. Investigated with CT-CAP: inflammatory looking 7mm lung nodule left upper lobe, enlarged left hilar, aorto-pul...

Introduction: The current UK guidelines (NICE TA791) recommend the use of romosozumab, a monoclonal sclerostin inhibitor, for patients at high imminent risk of fragility fractures. However, elderly patients with a very high risk of fractures often exhibit frailty and other comorbidities. This retrospective survey was conducted in a major trauma centre in northern England to evaluate the potential utilisation of romosozumab in a real-world setting.<p class=...

Introduction: Thyroid storm presents as multiorgan dysfunction. Diagnosis is purely clinical, and early diagnosis improves the outcomes.Case Presentation: 45-year-old lady without significant illness presented with breathlessness, productive cough, anxiety, and weight loss. Chest x-ray showed right pleural effusion and left consolidation. She was in fast AF with NT-proBNP >27000. initially treated as chest sepsis wit...

Introduction: AIT1 usually occur on a background of Graves’ disease or toxic nodule goitre. The disease usually requires higher doses of carbimazole than Graves’, might need rescue thyroidectomy, and can be treated with radioiodine with higher than standard radioiodine doses after iodine contamination has come down.Case Presentation: 57-year-old gentleman with history of HTN, T2DM, dyslipidemia, aortic stenosis...

A 32-years-old lady was admitted with raised calcium. She had palpitation, sweating, 3 stones weight loss and neck swelling. She was diagnosed with Graves’ disease 5 months ago. Her mother had history of thyroid disease but no family history of hypercalcaemia. She had a small goitre and lid lag on examination. On admission, adjusted calcium was 3.04 mmol/l. PTH was < 0.5 pmol/l. Phosphate, vitamin-D, kidney functions, cortisol, myeloma screen and ACE levels ...

Introduction: Growth hormone secretogogues (GHS) are popular among body building communities as muscle bulking agents. We present an interesting case of new onset diabetes induced by a combination of GHS and selective androgen receptor modulators (SARMs).Case report: A 34-years body builder was referred by his GP due to a 3-week history of polyuria, polydipsia and fatigue. He had recently used one cycle of a combination tablet which contained Ibutamoren ...

Introduction: A novel classification of adult onset DM into five subgroups: Severe Autoimmune Diabetes (SAID); Severe Insulin-Deficient Diabetes (SIDD); Severe Insulin-Resistant Diabetes (SIRD); Mild Obesity-Related Diabetes (MOD); and Mild Age-Related Diabetes (MARD) has been postulated. We aim to formulate a consensus statement towards reassessing gliclazide use based on cluster classification of diabetes mellitusMethods: A virtual collaborative educat...

Case history: A 61 year old male with a background of diabetes mellitus Type 2 and congestive cardiac failure (CCF) was diagnosed with Cushing’s disease in 2014 following identification of severe osteoporosis through investigations for non-traumatic vertebral fractures causing paraplegia.Investigations: He had high ACTH and cortisol levels which failed to suppress on low and high dose dexamethasone suppression tests, hypogonadotrophic hypogonadism a...

Background: The management of Cushing’s disease can be challenging especially when patients can present with sepsis and severely immunocompromised with limited oral medications to achieve cortisol control. We review a case of Cushing’s disease and the medical management of Cushing’s disease.Case Report: A 54 year old female presented with symptomatic hyperglycaemia with truncal obesity, proximal muscle weakness, right posterior thorax haem...

Background and aim: The Department of Health and NHS Plan both recognise that sending patients copies of clinic correspondence can help inform and empower them. At St Helens and Knowsley Teaching Hospitals NHS Trust, Endocrinology Clinic we routinely provide patients with a copy of the clinic correspondence sent to their General Practitioner (GP), unless patients specifically opt out. Our aim was to evaluate patients’ views on receiving such copy correspondence following ...