Endocrine Abstracts

Section 1: A 77 year female was referred by her GP in May 2019 for abnormal thyroid function tests (TFT) which were requested due to new diagnosis of atrial fibrillation. The patient was otherwise asymptomatic and clinically euthyroid. Family History was negative for thyroid abnormalities. On enquiry, the patient revealed that she had abnormal thyroid function tests associated with a large goitre in 1970s and subsequently underwent partial thyroidectomy followed by radioactive...

Background: Benign adrenal incidentalomas (AI) are found in 3-5% of adults. All patients should undergo a 1 mg -overnight dexamethasone suppression test (1 mg -DST) to exclude cortisol excess (non-functioning adrenal tumours, NFAT; serum cortisol ≤50 nmol/l) or diagnose possible mild autonomous cortisol secretion (MACS; serum cortisol >50 nmol/l). Current guidelines discourage repeating hormonal work-up in patients with benign AI. However, data underpinning this reco...

Introduction: T2DM is one of the main causes of morbidity and mortality in the UK. Epigenetic mechanisms impact gene expression and could predispose individuals to a particular metabolic phenotype. We investigated association of LINE-1 methylation (a surrogate of global DNA methylation) with cardiometabolic parameters in a longitudinal cohort of T2DM patients.Methods: Global LINE-1 DNA methylation in blood-derived DNA samples from 795 (men 60%, women 40%...

Introduction: T2DM is one of the main causes of morbidity and mortality in the UK. Epigenetic mechanisms impact gene expression and could predispose individuals to a particular metabolic phenotype. We investigated association of LINE-1 methylation (a surrogate of global DNA methylation) with cardiometabolic parameters in a longitudinal cohort of T2DM patients.Methods: Global LINE-1 DNA methylation in blood-derived DNA samples from 795 (men 60%, women 40%...

Section 1: Case history: A 61-year-old lady was referred by her GP to our endocrine clinic with abnormal thyroid function tests (TFTs) incidentally identified in routine blood tests. She had no symptoms suggestive of thyrotoxicosis apart from occasional palpitations when using inhalers for asthma. She had no family history of endocrine significance. She was on salbutamol, salmeterol, fluticasone inhalers and laxatives. Physical examination was unremarkable with no goitre. ...

Background: The aetiology of hyponatraemia in SARS-CoV-2 (COVID-19) is complex. Early studies have suggested a syndrome of inappropriate anti-diuretic hormone picture. We undertook a real-world retrospective analysis of patients with hyponatraemia and COVID-19 hospitalised over a 12-month period and evaluated practice against European hyponatraemia guidelines to see if initial investigations and management were appropriate. Additionally, we evaluated whether hyponatraemia in C...

Background: Dyslipidaemia, a major risk factor for cardiovascular disease (CVD) is considerably increasing in patients with diabetes. The purpose of the study was to evaluate the lipid profiles of diabetes patients attending Apollo Sugar Clinics across India.Methods: The current study was a retrospective analysis of electronic medical records of 1487 type 2 diabetes (T2DM) patients who registered at (Dec 2014 to Oct 2016) Apollo Sugar Clinics, across Ind...

Background: For patients in an adrenal crisis, the timely administration of parenteral hydrocortisone can be life-saving. Data from the Addison’s Disease Self-Help Group found that a large proportion of adrenal crises occur out of hospital, with many patients relying on the emergency services for initial parenteral hydrocortisone administration. Despite regular patient education (including parenteral hydrocortisone self-administration) and recommendations to wear steroid...

Low IGFBP2 is associated with the metabolic syndrome, but high IGFBP2 is longitudinally associated with worsening renal function. IGFBP2 binds IGF2 (and IGF1) and modified IGF bioavailablilty. The aim of our study was to identify whether baseline IGFBP2 concentrations were associated with all-cause and cardiovascular mortality in type 2 diabetes.554 subjects (59.3% male, mean age 63.7 (S.D. 10.7)) with type 2 diabetes from the Salford Diab...

Associations of Insulin-like growth factor-II with cardiovascular risk have been inadequately studied. We studied longitudinal associations of IGF-II with cardiovascular risk factors in people with type 2 diabetes. Subjects and methods: 462 type-2 diabetes patients aged 26 to 86 years from the Salford Diabetes cohort were analysed. Longitudinal clinical information was extracted (years 2002–2009) from an integrated database of primary care and hospital data. IGF-II was me...