Endocrine Abstracts

Pericentromeric inversion of the heterochromatic region of chromosome 9 has been reported in almost 4% of the cases of male infertility.Objective: Determining the karyotype from an infertile couple scheduled to perform IVF.Materials and methods: Slides with metaphasic chromosomes were GTG-banded according to standard protocol for cytogenetic analysis (karyotype). FISH analysis – inverted DAPI (4′-6-diamidino-2-phenylindo...

Insulin resistance is possibly playing an underlying pathogenic role in the polycystic ovary syndrome (PCOS) and although is not a part of its definition, it appears in 50-90% of PCOS women. Polycystic ovary syndrome is also frequently associated with obesity; women suffering of PCOS seem to be at a great risk of developing a metabolic syndrome.Objectives: The aim of our study was to determine the prevalence of the metabolic syndrome in a population of 4...

Introduction: Subacute thyroiditis (ST) is a self limited condition; relapse is rarely seen. Anterior cervical complains and inflammatory syndrome is highly suggestive.Aim: We report a series of female cases associating arelapse of ST which was confirmed after the admission for atypical distant symptoms as diffuse headache or ear pain.Material and Methods: The endocrine profile is presented.Results: A 48-year...

Introduction: Struma ovarii is a rare condition which elicited considerable interest because of its many unique features like its relationship to teratoma and differentiated thyroid cancer. The most common thyroid carcinomas to arise in struma ovarii are papillary and follicular.Objectives: We describe two patients with differentiated thyroid carcinoma originating from malignant struma ovarii.Results: Our index patient is a 32-year...

Background: Hypothyroidism is defined as an elevated TSH (thyroid-stimulating hormone) and/or decreased free thyroxine (FT4) levels. Levothyroxine is now one of the most widely prescribed medications. However, treatment indications are controversial in subclinical hypothyroidism, defined as high TSH with normal T4 levels. Methods: We performed a cross-sectional study reviewing the blood samples received in our Laboratory for TSH determination during the ...

Introduction: Infertility investigations include uterine–ovarian ultrasound. The incidental finding of a tumor in a young female might associate a potential severe prognosis in otherwise completely asymptomatic patient.Aim: We present a case of a young female with an accidentally discovered ovarian tumor.Case report: S.M. 35-year female patient is admitted for infertility. Her family and personal medical history is irrelevant....

Background: Cushing’s syndrome is a rare condition in pregnancy, because infertility is one of the main features of this pathology. Association between pregnancy and cortisol excess involves a high rate of mortality and morbidity for mother and fetus. Hypertension, preeclampsia, diabetes, miscarriage, preterm delivery or sudden intrauterine death can occur. We describe a case of a pregnancy in a patient with a history of Cushing’s Syndrome, diagnosed during the pre...

Osteoporosis is a polygenic disease. The intensive search for genetic markers has led to the identification of several genetic polymorphisms, associated with the decrease of bone tissue and therefore a higher risk of osteoporosis.The study aimed to evaluate estrogen receptor alpha (ESR1) and vitamin D receptor (VDR) polymorphisms in postmenopausal women with or without osteoporosis and their correlations with bone markers and adipocytokines.<p class=...