Endocrine Abstracts

Introduction: 30% of the adult population has high blood pressure. About 6% of the hypertension may be caused by primary aldosteronism and very rare by primary hyperparathyroidism. The combination of these two causes is very rare.Case report: Our patient is women (age 50) with a 21 year long history of uncontrolled hypertension. Treatment of hypertension consist of a beta-blocker, calcium channel blockers, angiotensin converting enzyme inhibitor, loop di...

Introduction: Some patients develop excessive bone metabolism supression during antiresorptive therapy. Low remodelling rate enables increase in tissue mineralisation density and homogenicity of bone trabeculae. Increase in density makes micro-damage more likely. Increased homogenicity provides less resistance to spread of the micro-cracks and slowed remodelling slows down removal of microdemage. All this leads to increased bone fragility.Aim: To establi...

Background and aims: The distribution of arterial occlusive disease is not fully explained in diabetes. The aim of this study was to examine the prevalence of CHD and PAD in diabetic patients complicated by abnormal test of distal autonomic function (Neuropad®) and large fibre neuropathy.Materials and Methods: 237 patients were analysed, M/F 111/126, age (mean±SD) 61.3±9.5years (ys), diabetes duration 16.4±10.6ys., type 1 n=22 (9.3%),...

Many studies show insufficient and inadequate vitamin D and calcium levels in postmenopausal women with osteoporosis, thus emphasising the need for supplementation therapy.Aim of the study: To determine vitamin D (25(OH)D) and ionised calcium levels in women treated for postmenopausal osteoporosis at our Clinic in the course of year 2009.Materials and methods: We prospectively followed up 116 women at the age of 59.38±5.55 (mi...

Introduction: Autoimmune thyroid disease is often associated with other autoimmune diseases. Coeliac disease is one of those autoimmune diseases, together with is wide spectrum of intestinal and extraintestinal manifestations. Atrophy of intestinal mucosa, one of the characteristics of coeliac disease, among everything else, leads to poor absorption of l-tyroxine used in therapy of hypothyroidism.Aim and results: We like to present a clinical case of our...

Introduction: Some recent data indicates that high levels of homocysteine (Hcy) can be independent risk factor for osteoporosis and fractures in elderly. There are few explanations how homocysteine influence bone resorption and probably modify effect of therapy for osteoporosis. 1. Hcy interferes with collagen cross-linking. 2. High levels of Hcy specially stimulate resorptive activity of osteoclasts in vitro. 3. Hcy interfere bisphosphonates binding to hydroxyapatite.<...

COGHD may be of genetic origin associated with deficiency of other pituitary hormones. Non treatment with GH in these cases can cause metabolic and other disturbances. The aim of this research was examining consequences of non treated COGDH in three sisters with familial hypopituitarism. Three sisters 60-, 59- and 54-year-old with familial hypopituitarism (GH,TSH, gonadotropin and prolactin deficiency) which was diagnosed 46 years before were examined. Substitution therapy per...

Background: Metabolic disturbances could contribute to poor outcome after acute myocardial infarction (AIM) in type 2 diabetic patients.Objective: We examined the acid base disturbances that could contribute to poor prognosis after MI among type 2 diabetics suffering AMI.Methods: Parameters of acid base status and blood lactate level were compared (using one and two – way ANOVA) in 160 age-matched individuals. Forty of them we...

The prevalence of osteoporosis among men is not well-documented. The aim of this cross-sectional study is to analyze results of DXA scans preformed in males in Clinical center of Vojvodina between years 2009 and 2016. Form the total of 2006 fist DXA scans performed in 7 years period there was 14.8% of males. DXA scan was indicated by the rheumatologists, internists and endocrinologists predominantly for suspected secondary causes of osteoporosis. We divided male subjects in gr...

Introduction: Phthalates are ubiquitous endocrine disruptors (EDs). EDs induce obesity. MEP and MEHP affect thyroid function.Aim: Estimation of burden of MEP and MEHP in our population, evaluation of leptin in obese MEP and MEHP positive and negative subjects and evaluation of connection between leptin, MEP, MEHP and thyroid indicators in that subgroup. Materials and methods: a cross-sectional study, with 201 subjects divided into MEP/MEHP positive and n...