Endocrine Abstracts

Adjara is a region in Georgia with high level at iodine deficiency.The aim of the present work was to study the subclinical dysfunctions of thyroid gland in women older than 40 years whose thyroid state hadn’t been examined before.Materials and Methods: From 1998 to 2005 693 women aged 40–78 had been examined. Primary examination was done by different specialists.All women were tested on thyreotropi...

Aim: Non-alcoholic fatty liver disease (NAFLD) is a common comorbidity with type 2 diabetes and a few agents such as pioglitazone and metformine has been shown to beneficial effects. SGLT-2 inhibitors are used in the treatment in type 2 diabetes (T2D). It has been shown that they can the effectivenes of improve liver function in patients with NAFLD as well as in T2D. In our study we aim to elucidate the effectiveness of SGLT-2 inhibitors as second line treatment for NAFLD pati...

A decrease in insulin sensitivity (IS) is associated with increasing visceral adiposity. An inverse correlation has been demonstrated between Intramyo-(IMTG) and intrahepatocellular triglyceride (HCTG) concentrations and IS. Patients with AA have reduced IS but IMTG and HCTG content has not been studied.Eight patients with AA (IGF-I >ULN, median 1.83×ULN (range1.16–4.38) ((6 M), median age 39.5 (range 23–66) years, median BMI 30.6(23.5...

Background: Although it has been conceived that type 2 diabetes mellitus (DM2) is associated with increased myocardial triglyceride (TG) accumulation, it is unknown whether this can be influenced by modifying plasma non-esterified fatty acids (NEFA) levels. We therefore determined in uncomplicated DM2 whether modifications in plasma NEFA influence myocardial TG content and myocardial function.Research design and methods: Myocardial TG content and left ve...

Observational studies conducted during the past two decades provide evidence of an association of dietary fructose consumption with obesity and metabolic diseases as non-alcoholic fatty liver disease or insulin resistance / type 2 diabetes mellitus. However, these associations are challenged by the fact that it is difficult to adjust the results of such studies for excessive caloric intake, which often co-exists with high fructose intake, e.g., by consumption of sugar-sweetene...

Hypertension and diabetes are prevalent conditions. Population studies suggest that blood pressure in excess of 140/90 mmHg is found in nearly 30% of adults while type 2 diabetes occurs in 3-4%. However, both conditions are strongly age-dependent, and exhibit large geographical variations. Non-european populations typically have much higher prevalence rates. Worldwide, there has been a dramatic increase in the occurrence of type 2 diabetes. It has long been known that these co...

Background: Hungry bone syndrome is a relatively uncommon but serious complication in patients who underwent parathyroidectomy for primary hyperparathyroidism. The syndrome is described as a hypocalcaemia (corrected serum calcium<2.1 mmol/L) lasting longer than four days after parathyroidectomy in the presence of a normal or elevated parathyroid hormone (PTH). Treatment is challenging and guidelines are based on clinical experience. To restore calcium levels high doses of ...

Background: Distinguishing pseudo-Cushing syndrome (PCS) from mild forms of Cushing’s disease (CD) is a challenge. The dexamethasone-Corticotropin Releasing Hormone test (dex-CRH) assumes that cortisol response to CRH is preserved in CD while suppressed in PCS after the low dose dexamethasone suppression test (LDDST). Methods: Persons with a suspicion of CD based on mild clinical features and a positive first-line screening test were included. They ...

Initial presentation and work-up: A 42-year-old man was referred to the endocrinologist because of an incidentaloma of the right adrenal with a maximum diameter of 4.2 cm on echography of the abdomen. Echography was performed because the patient presented with icterus. An abdominal CT scan confirmed a right adrenal mass with a maximum diameter of 5.1 cm. The intensity of the adrenal adenoma amounted 39 Hounsfield units. The patient did not have a significant medical history, e...

In true precocious puberty, the increased gonadal steroid secretion increases height velocity, somatic and psychosocial development, and the rate of skeletal maturation and can lead to short adult height. The aim is to assess the impact of suppression therapy of CPP with triptorelin on final adult height and the timing of menarche and pattern of menstrual cycle post-treatment.Materials and methods: Nineteen girls, with CPP, which had completed at least t...