Searchable abstracts of presentations at key conferences in endocrinology

ea0016p574 | Obesity | ECE2008

Development of metabolic syndrome is associated with impaired quality of life: longitudinal data from the North West Adelaide Health Study

Phillips Patrick , Baldock Katherine , Chittleborough Catherine , Taylor Anne

Background and aims: Longitudinal data from the North West Adelaide Health Study (NWAHS) were used to examine the effect of development of metabolic syndrome between Stage 1 (2000–2003) and Stage 2 (2004–2006) on quality of life.Material and methods: The NWAHS is a random, representative sample of people aged 18 years and over living in the north west region of Adelaide. Participants were recruited via telephone interviews to attend the clinic....

ea0015p132 | Diabetes, metabolism and cardiovascular | SFEBES2008

In obese men, lower circulating androgens restrain generation of oestrogens by aromatase, with adverse metabolic effects

Gibb Fraser , Reynolds Rebecca , Phillips David , Andrew Ruth

Objective: Aromatase deficiency in mice or men prevents conversion of androgens to oestrogens and results in central obesity and insulin resistance. In idiopathic obesity, higher aromatase mRNA levels in adipose tissue predict peripheral rather than central fat distribution, but any contribution of aromatase to metabolic complications is unknown. Here, we measured plasma steroids in a large cohort of men and post-menopausal women, in whom aromatase is the major source of oestr...

ea0015p319 | Steroids | SFEBES2008

Sleep and cortisol profiles in healthy volunteers using an automated blood sampling machine

Phillips Suzanne , Henley David , Wilson Sue , Nutt David , Lightman Stafford

Sleep and cortisol cycles have a complex inter-relationship that is not fully understood. Slow wave sleep appears to have an inhibitory effect on cortisol production but the effect of other stages is not so clear. From diseases, such as Addisons disease and Cushings syndrome, we know that cortisol levels have an impact on the quality of sleep. In insomnia and depression, both sleep and cortisol is altered.To investigate this relationship properly a minim...

ea0012p32 | Clinical case reports/Governance | SFE2006

Problems in the diagnosis of disorders of sex development

Honour JW , Stanhope R , Hughes IA , Phillips I

A girl with family history of a disorder of sex development (DSD) was referred for biochemical investigations and genetic analysis. Parents were consanguineous and a sibling was thought to have partial androgen insensitivity although androgen receptor gene analysis does not fully explain the phenotype. A maternal uncle with perineal hypospadias and a maternal aunt also had the mutation. One sister was normal, one brother had dextrocardia and another brother had mental retardat...

ea0009p118 | Endocrine tumours and neoplasia | BES2005

The natural history of post-traumatic hypopituitarism: Implications for assessment and treatment

Agha A , O'Kelly P , Tormey W , Phillips J , Thompson C

Hypopituitarism has been reported in 28-65% of long-term survivors of traumatic brain injury (TBI). We attempted to define the natural history of post-traumatic hypopituitarism in order to devise guidelines for the optimal timing of patient assessment and hormone replacement.Fifty consecutive patients with severe or moderate TBI were enrolled in a prospective study of pituitary function during the acute phase, at 6 months and, at 12 months following TBI....

ea0007p154 | Neuroendocrinology and behaviour | BES2004

Prevalence of hypopituitarism in survivors of traumatic brain injury

Agha A , Rogers B , Tormey W , Phillips J , Thompson C

Recent evidence suggests a high prevalence of neuroendocrine dysfunction in patients following traumatic brain injury (TBI), but dynamic anterior pituitary assessment were performed in relatively small number of patients and posterior pituitary function remains poorly investigated.We studied 102 consecutive patients (84 males) who had survived severe or moderate TBI [initial Glasgow Coma Scale (GCS) score 3-13] at a mean (+/- standard deviation) of 19 +/...

ea0007p166 | Neuroendocrinology and behaviour | BES2004

Are cortisol responses to psychological stress related to size at birth in humans?

Ward A , Moore V , Steptoe A , Robinson J , Phillips D

Prenatal manipulations in animal models result in lifelong alterations in the stress responsivity of the hypothalamic-pituitary-adrenal axis (HPAA). While several human studies have found raised 0900h cortisol concentrations in low birthweight individuals, twenty-four hour cortisol profiles do not vary according to birthweight (a marker of adverse antenatal exposures). One explanation for this dichotomy is that 0900h cortisol concentration measured in a novel clinic setting ma...

ea0007p274 | Clinical case reports | BES2004

Crooke Cell Adenoma: case report of a rare but aggressive tumour

O'Shea L , Farrell M , Phillips J , Kinsley B , Firth R

Crooke Cell Adenoma (CCA) is a rare variant of ACTH-secreting corticotroph adenoma. Its importance derives from its aggressive behaviour, association with Cushings Disease and differentiation from metastatic carcinoma. A sixty-year old shopkeeper presented with a two-year history of generalised aches and pains, proximal muscle weakness, increased facial hair and easy bruising. She had also noticed an increased abdominal girth and facial rotundity. There was an eight-year histo...

ea0006p41 | Endocrine tumours and neoplasia | SFE2003

Intraoperative parathyroid hormone (PTH) determinations

Honour J , Phillips I , Hodkinson R , Nelson D , Kurzawinski T

The outcome of parathyroid surgery is often not clear for at least 24 hours after an operation. Frozen section is not always helpful in distinguishing between adenoma and hyperplasia. Minimally invasive surgical techniques are being refined so the need for perioperative assurance about the effects of surgery has increased. PTH assays have been adapted to give results in less than 20 minutes. We have tested the value of intraoperative PTH measurements in 10 surgical cases under...

ea0004p11 | Clinical case reports | SFE2002

Surgical Stimulation of a Silent Corticotroph to Secrete

Quinn N , Phillips N , Nelson M , Bridges L , Belchetz P

A 71 year old woman presented with visual loss. MR scanning demonstrated a massive invasive pituitary adenoma. She had no features of endocrine dysfunction. 0900hrs cortisol was 278nmol/L. Haemorrhage limited transphenoidal surgery to biopsies. Postoperative CSF leak was repaired 3months later. Histology revealed a corticotroph adenoma on immunostaining.At endocrine follow-up, afternoon cortisol was 645nmol/L, and 875nmol/L fasting, falling after glucago...