Endocrine Abstracts

Background: Calcification occurs physiologically in bone and pathophysiologically in the vasculature. Cardiovascular diseases are among the most common causes of death within patients with chronic kidney disease and crucial for kidney transplantation (RTX) outcomes.Methods and aim: We investigated the pattern and the onset of expression of regulators of calcification (RC) in the arteria iliaca externa in 26 donors (D) and 25 recipients (R) of RTX to iden...

Introduction: Current medical and nursing scores have limited efficiency and safety profiles to assign the most appropriate treatment site to patients with lower respiratory tract infections (LRTIs). We assessed the potential of a combined score of CURB65 with proadrenomedullin (ProADM) levels and the adapted post-acute discharge score (PACD) for triage and discharge management decisions. We aimed to identify the proportions of patients who would be best cared for at different...

Study objective: We investigated the effect of linsitinib, a dual small-molecule kinase inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) and the Insulin receptor (IR), on Graves’ Disease and thyroid eye disease. Graves‘ disease (GD), also known as ‘Basedow’s disease‘, is the most common cause for hyperthyroidism, typically presenting in patients between 40-60 years. GD is an autoimmune condition of the thyroid which is caused by autoanti...

Background: Although anti-VEGF RTKIs have been tested in patients with NETs over the last 2 decades, no study to date has benchmarked efficacy and toxicity of these drugs in this patient population.Methods: A literature search was performed to identify all phase II and phase III studies of anti-VEGF RTKIs in patients with NETs published between January 1, 2000 – July 31, 2021. Major trial databases (e.g. Medline, EMBASE, Cumulative Index of Nursing ...

Accumulating evidence suggests that the immunological landscape plays a key role in the progression of neuroendocrine liver metastases (LM-NENs), which is often characterised by immune cell infiltration. Anti-tumour functions of infiltrating lymphocytes are often silenced through hyper-expression of inhibitory checkpoint receptors (CRs) such as PD-1, but favourable outcomes with anti-PD-1 therapy have been low. Recently, functional soluble (cell-free) CRs beyond PD-1 have been...

Phaeochromocytoma-driven Ectopic ACTH Syndrome (EAS) is rare. We report the case of a 31-year-old female, who presented with abdominal pain and vomiting. She had clinical features of severe Cushing’s syndrome (proximal myopathy, bruising, refractory hypertension and acute confusion). Admission investigations revealed hypokalaemia (2.1mmol/l [3.5-5.5mmol/l]) and a 4.5cm left adrenal lesion with a ’bulky’ right adrenal on CT abdomen. She was diagnosed with hyperte...

Background: Limited contemporary data exist with which to counsel women with Turner Syndrome (TS) with regards to risks associated with pregnancy. We conducted a multicentre UK retrospective cohort study to determine the characteristics and outcomes of pregnancy in women with TS.Method: Retrospective cohort 20-year (2000-2020) study including 16 UK tertiary referral maternity units. Data were collated from case notes review, and maternal outcomes, obstet...

The majority of patients with Cushing’s syndrome are ACTH-dependent, but the diagnosis of ACTH-dependence, and then the differential diagnosis between Cushing’s disease and the ectopic ACTH syndrome, is dependent on the measurement of ACTH. In the mammalian adult anterior pituitary, POMC is cleaved into a variety of products including the ‘normal’ ACTH(1-39). In the pars intermedia (present in the human fetus and most mammals), ACTH is cleaved further by th...

The majority of patients with Cushing’s syndrome are ACTH-dependent, but the diagnosis of ACTH-dependence, and then the differential diagnosis between Cushing’s disease and the ectopic ACTH syndrome, is dependent on the measurement of ACTH. In the mammalian adult anterior pituitary, POMC is cleaved into a variety of products including the ‘normal’ ACTH(1-39). In the pars intermedia (present in the human fetus and most mammals), ACTH is cleaved further by th...

Background: The incidence of type 2 diabetes in childhood in the UK is increasing. It is often an aggressive disease associated with poor health outcomes. Despite this, there is little formal training and evidence based guidance.Objectives and method: A questionnaire was sent to each paediatric diabetes unit in England and Wales, evaluating variation in practice, training and confidence in the management of type 2 diabetes.Results:...