Endocrine Abstracts

Introduction: Asprosin is a novel adipokine that is released in response to fasting and can elicit orexigenic and glucogenic effects. Circulating asprosin levels are elevated in a number of cardio-metabolic diseases, including obesity and type 2 diabetes mellitus. In vitro studies have reported pro-inflammatory effects of asprosin in pancreatic β-cells and skeletal muscle cells, which appear to be mediated via a toll-like receptor 4 (TLR4) mediated pathway, and m...

Variability in treatment response with respect to GLP1 agents is well-accepted but incompletely understood. In a specialist GLP-1 clinic at UHCW, we describe a case of improved therapeutic response following change in injection site. Currently, advice is injection in the abdomen or thigh.A 61 year old man was commenced on Liraglutide 1.2 mg subcutaneous OD injection, in 2013. Previously managed with glimepiride 4 mg and ...

Variability in treatment response with respect to GLP1 agents is well-accepted but incompletely understood. In a specialist GLP-1 clinic at UHCW, we describe a case of improved therapeutic response following change in injection site. Currently, advice is injection in the abdomen or thigh.A 61 year old man was commenced on Liraglutide 1.2 mg subcutaneous OD injection, in 2013. Previously managed with glimepiride 4 mg and ...

Background: Hyperprolactinaemia is the common endocrine disorders. More commonly diagnosed in women due to menstrual irregularity, infertility and galactorrhoea. Hyperprolactinaemia can be due to many physiological stimuli such as stress, sleep, exercise, medications, primary hypothyroidism, renal failure, chest wall lesion. Stress of venepuncture can contribute to hyperprolactinaemia as well.Patient and methods: We conducted a retrospective analysis of ...

A 26-year-old Caucasian male presented to the joint infertility outpatients clinic with primary infertility. His medical history included hypertrophic cardiomyopathy (HCM) due to genetically confirmed MYH7 sarcomere protein mutation, treated with implantable cardioverter-defibrillator while his partner was a healthy 24-year-old Caucasian nulliparous female. Initial investigations showed hypertestosteronemia (Testosterone: >51.0 nmol/l) and azoospermia, hence the c...

We present the case of a 58-year-old woman who presented 30 years ago. She was noted to have abdominal obesity, moon-face and skin bruising/thinning, as well as hypertension. Serum cortisol was elevated and she was presumed to have Cushing’s disease (although we have no record of dynamic tests or imaging from the time of her original presentation). Owing to her desire for future fertility, she underwent bilateral adrenalectomy at the age of 31 years. She received hydrocor...

The aim of this audit was to assess the efficacy of vitamin D replacement therapies (oral Ergocalciferol D2 and Cholecalciferol D3) on serum Vitamin D (25(OH)D), when dispensed to endocrine outpatients. After exclusions, clinic records of 54 patients were analysed for pre- and post dosage serum 25(OH)D levels, PTH levels, total dosage given, and duration of replacement. Results: Mean total dose of D2 (n=24) was 350,000 (IU) against D3 (n=30) 305,000 (IU), with av...

Background: Serum biomarkers which correlate with pituitary tumour growth would be valuable in the treatment and follow-up of patients with pituitary adenomas, particularly non-functioning adenomas. Vascular Endothelial Growth Factor (VEGF) mRNA is upregulated in almost all tumours, whereas matrix metalloproteinases 2 and 9 (MMP 2 and 9) have been demonstrated to be important in tumour vascularisation and invasion, particularly in prolactinomas.Aim: The ...

Introduction: Osteogenesis imperfecta (OI) is classified on the basis of molecular genetics, mode of inheritance, clinical and radiological findings. The genes implicated are either COL1A1 or COL1A2. We report a case of a novel mutation of OI in the COL1A2 gene.Case: A 24-year-old teacher with type 1 Diabetes Mellitus, presented to our Endocrine Clinic with recurrent fractures since childhood. At 7 months old, she fractured her left leg. At...

Objectives: Visfatin and monocyte-chemoattractant-protein-1 (MCP-1) are elevated in cardiovascular pathologies, insulin-resistant and dysmetabolic states. Visfatin has been reported to exhibit pro-angiogenic actions in human endothelial cells by the induction of endothelial gelatinases and VEGF. Given MCP-1’s well described pro-angiogenic properties we sought to study the potential interaction between visfatin, MCP-1 and VEGF in human endothelial cells. More importantly, ...