Endocrine Abstracts

Phosphorus is involved in energy storage, metabolism, nucleic acids, cell membrane function, cell signaling; it is a fundamental constituent of skeleton and teeth. Pi homeostasis is regulated mainly by three hormones, namely parathyroid hormone (PTH), vitamin D and Fibroblast Growth Factor 23 (FGF23). Additionally, sex hormones are known to decrease circulating Pi levels, by reducing renal tubular reabsorption through direct and indirect effects on renal phosphate channels and...

Aim: Autonomic cortisol secretion (ACS) is a clinical picture without overt signs of Cushing’s Syndrome despite adrenal adenoma and ACTH-independent cortisol secretion. These patients, who currently do not have a standard treatment, are followed up, especially for known comorbidities of hypercortisolemia such as obesity, diabetes mellitus (DM), hypertension, osteoporosis, and hyperlipidemia. However, it remains unclear how long the patients will be followed and when the t...

Before the availability of glucocorticoids as drugs, the majority of patients with primary adrenal insufficiency (AI) died within 2 years of diagnosis. Today patients with AI receive life-long replacement therapy with glucocorticoids with the assumption that life expectancy is normal. Recent studies have, however, shown excess mortality in patients with both primary and secondary AI mainly due to cardiovascular diseases and infections. Patients with AI also have increased rate...

Introduction: Radioactive iodine (RAI) is a commonly used treatment modality in Graves’ hyperthyroidism. Patient choice is a major factor in advising radioiodine but there are few data on patient satisfaction following treatment.Method: QuestionnaireAn anonymised questionnaire was distributed to 100 individuals on the thyroid register with RAI treated Graves’ hyperthyroidism. The survey included questions relating to side...

Previous studies reported increased prevalence of metabolic syndrome (MS) and mortality rates from cardiovascular causes in hypopituitary patients. Fatty liver disease was added recently to this unfavorable cardio-metabolic phenotype. We studied the prevalence of MS and non-alcoholic fatty liver disease (NAFLD) in unselected cohort of 282 hypopituitary patients (146 male), mean age 49.2±15.1 years, on standard replacement therapy (76.4% received l-thyroxin, 76% hydrocorti...

Introduction/Background: PRRT is a high cost treatment for progressing Neuroendocrine tumours. Patients and healthcare providers invest heavily in the treatment journey that lasts a number of months.Aims: To assess the level of patient satisfaction with the PRRT service, to indicate areas for possible improvement and good practice and serve as a baseline for future assessments.Material and ...

Background: Pheochromocytoma and paraganglioma (PPGL) are rare endocrine tumours that secrete catecholamines. Methoxycatecholamines in free plasma or fractionated methoxycatecholamines in 24-hour urine collections are the recommended tests for the diagnosis of pheochromocytoma, based on which patients are referred for surgical removal of the adrenal gland. However, false-positive results from these tests remain a problem and some patients are referred for adrenalectomy due to ...

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Background and aim: KS has been classically described as characterized by hyperestrogenism and elevated serum E2 together with increased gonadotropins and low-to-normal serum testosterone (T). In literature, data on increased serum E2 are not solid. The aim of this study is to meta-analyse data from studies evaluating serum E2 in both KS and healthy subjects (HS) in order to verify if E2 is increased in KS.Meth...

Introduction: Primary aldosteronism (PA) causes 15–25% of cases of drug-resistant hypertension (RBP). Adrenal vein sampling (AVS) is considered the gold standard for diagnosis of aldosterone aberrant secretion origin. The distinction between unilateral and bilateral disease dictates the targeted therapeutic approach, with surgery for aldosterone producing adenomas and medical therapy for patients with bilateral hyperplasia. As AVS is an invasive, not well standardized pr...