Endocrine Abstracts

Background: Genotype-phenotype correlations between various RET mutations and clinical manifestations of MEN 2 syndrome are well established. A discussion is still open if the FMTC phenotype really exists or if it is just a MEN2A variant. Aim of this study was to verify if the phenotype corresponding to the V804M germline mutation is restricted to FMTC.Methods: During the last 25 years, we have identified 200 families with a hereditary form of M...

There are many effects on adipose tissue metabolism of housing mice at different temperatures. Considering the situation from a thermoregulatory perspective, it may – in retrospect – be evident that one cannot expect to observe any effect of e.g. UCP1 ablation under “normal housing” conditions. This is because at normal animal house conditions (≈20 °C), the mice experience significant cold, and they must increase their metabolism by 50-100 % (as ...

Background: Most common tumors in the suprasellar region are adenomas of the pituitary gland, craniopharyngiomas, cystic lesions (Rathke’s cleft cysts). Supraselar meningiomas are rare and slow-growing tumors that usually arise from the tuberculum sellae or the chiasmatic sulcus. These tumors frequently invade the sella turcica because that they are mistaken for a pituitary tumor.Methods: A case seriesResults: We present a two...

Introduction: Minimally invasive surgery is an alternative surgical approach for primary hyperparathyroidism with less surgical trauma and anesthesia complications. Neck ultrasonography and scintigraphy are still the first step tools for localisating parathyroid lesions. Intact parathyroid hormone (PH) determination in washout samples is really very useful when parathyroid lesions can not be easily distinguished from thyroid lesions or sometimes lymph nodes.<p class="abste...

Objectives: Preoperative imaging studies are being commonly used in primary hyperparathyroid patients to increase cure rate and to decrease complication rate of surgery. In this study we correlated the surgical outcomes with localization studies performed by various radiologists.Method: A total of 174 patients with primary hyperparathyroidism in which healing of hypercalcemia achieved by parathyroidectomy were evaluated retrospectively. Since our hospita...

Background: The Ectopic ACTH Syndromes (EAS) often associated with severe hypercortisolism are really a challenge.Case presentation: We report the case of a 48-year-old woman, newly diagnosed with hypertension, hypokalemia despite renin-angiotensin blockers intake, and complaints of intense fatigue, muscular weakness, and easy bruising, which worse in four months. EAS was biochemically confirmed, but two urinary catecholamines collection were negatives d...

Objectives: To assess patient satisfaction with the transitional diabetes clinic service. Our transitional diabetes clinics (for 14–19 year olds) are run monthly by a multi disciplinary team comprising of a consultant, nurse and dietician each, from both adult and paediatric diabetes teams.Methods: An electronic tablet with the pre-programmed survey was handed out to 42 young people while they were waiting to be seen in clinic.<p class="abstext"...

Introduction: The aim of having an away day was to enhance relationships across three sites by improving the understanding of each other’s roles, their contributions and ways to provide mutual support. Also the intention was to establish parity through co-designing common practices of working effectively and developing quality improvement projects.Method: Staff members from three Paediatric Diabetes Teams within the same trust were invited to attend...

Endocrinologists are ideal teachers of physiology and biochemistry, major aspects of the underpinning of the science behind clinical practice. There are many methods that are successful in imparting this core knowledge to our medical students. Patients with endocrine disease also display symptoms and signs that that give clues to diagnoses, and the subject is ideal to serve as a broad general medical education.Evidence that teachers are effective comes f...

Case report: Adrenal pseudocysts are rare bening lesions that usually mimick solid tumors on imaging. Although they are asymptomatic and often discovered incidentally, distinguishing them from clinically important adrenocortical masses may be problematic before surgery. We report the case of a 50-years-old female who was referred to endocrinology outpatient clinic with a 54×58×50 mm sized mass in the left adrenal gland. Abdominal MRI which was performed because of ri...