Endocrine Abstracts

Spontaneous pregnancy in the course of Sheehan syndrome is extremely rare because of gonadotrophic insufficiency, which is almost present.The aim of our study is to analyse cases of pregnancies occurring spontaneously in patients with Sheehan syndrome.It is a retrospective study of 46 women who had a Sheehan syndrome diagnosed in the Internal Medicine and endocrinology department of Charles Nicolle Hospital during the period betwee...

Sheehan’s syndrome represents a rare cause of pituitary insufficiency, produced by an ischemic pituitary necrosis due to a severe haemorrhage at deliverance. Epidemiologic data indicate that, nowadays, this disease is quite rare in developed country.Aim: To determine and evaluate the clinical and hormonal characteristics of cases with Sheehan’s syndrome diagnosed and follow-up in our Clinic, during the last ten years.Subj...

The term Sheehan syndrome refers to the development of pituitary necrosis due to ischemia within a few hours of delivery. Usually, antecedent hypotension and shock are present, resulting most commonly from obstetric hemorrhage. In such instances evidence of adrenal and thyroid insufficiency should be sought. A classical symptom of Sheehan’s syndrome is the absence of lactation after delivery related to prolactin deficiency. We retrospectively analysed 64 patients who were...

Introduction: Sheehan Syndrome (SS) is a cause of hypopituitarism resulting from postpartum pituitary infarction. Its frequency is decreasing worldwide, particularly in developed countries due to advances in obstetric care. Case report: A 50-year-old female patient was admitted to the emergency department with complains of progressive pain in the lower hemithorax and abdomen. She also referred constipation, weight gain and asthenia. The initial laborator...

There are a limited number of studies investigating the immunological alterations accompanying the Sheehan Syndrome. The aim of this study was to evaluate lymphocyte subsets in these patients.Flow cytofluorometry was used for the immunophenotyping of peripheral blood leukocytes from 15 patients (mean age 61.6±11.3, range 34–75 years) and 25 healthy controls (mean age 56.7±10.6, range 34–80 years). The percentages of CD3+, C...

A 34-year-old lady attended clinic-requesting information on recombinant prolactin to assist with breast feeding as she was 32 weeks gestation with her third pregnancy having failed to lactate after her first two pregnancies.In 2003 she developed pre-eclampsia during her first pregnancy and required delivery by Ventouse extraction. She had a significant post-partum haemorrhage of 1200 mls with haemoglobin 7g/dl but no evidence of cardiovascular compromis...

Introduction: In our country, Sheehan syndrome is one of the most common causes of pituitary insufficiency in female patients.Case: A 54-year-old female patient developed cardiac arrest after an elective hip replacement surgery, and after 5 minutes of cardio pulmonary resuscitation, the rhythm returned to normal and the patient was intubated. Since she was hypotensive, she was given the infusion of noradrenaline after dopamine infusion, but despite this ...

Background: The blood supply of the pituitary gland comes via a portal circulation from the hypothalamus. During pregnancy, the anterior pituitary gland enlarges but the blood supply cannot increase, as it is derived from a capillary plexus. The pituitary is thus vulnerable to arterial pressure changes and infarction secondary to hypotension. We describe a case of a male patient with large pituitary adenoma who developed Sheehan’s like syndrome due to adenoma infarction s...

Introduction: Sheehan’s syndrome (SS) is the development of partial or complete hypopituitarism following parturition, preceded in most of the cases by severe postpartum hemorrhage. The disease continues to be common in some developing countries.Some of the anterior pituitary functions like gonadotrophic and corticotrophic secretions may be preserved in these women. The purpose of this observation is to reporte a rare case of spontaneous pregnancy occurs in a patient foll...

Introduction: Sheehan syndrome (SS), or postpartum pituitary necrosis, is a rare but potentially serious complication of postpartum. we describe a patient whose diagnosis of sheehan’s syndrome was delayed and revealed by a cardiovascular collapse.Case report: A 36 year old femele patient, admitted to the intensive care unit in a state of septic shock due to pyelonephritis, was intubated, ventilated and put on noradrenaline in SAP and antibiotic ther...