Endocrine Abstracts

Background: 20% of patients with acromegaly can have visual field defect due to compression of optic chiasm. This patient presented with visual field defect but no evidence of pressure effect on optic chiasm, but later found to have pituitary macroadenoma and acromegaly.Clinical Details: 59 yr old man presented 7 years ago to ophthalmologist with left inferior field defect of 2 months duration. The field defect was confirmed with perimetry. Subsequent CT...

IntroductionRenal disease in type 2 diabetes can be prevented and limited with early detection and management of the condition. We studied the adherence of renal guidelines introduced by national institute of clinical excellence (NICE), in patients who attended the annual review in the last 12 months.MethodsAudit standards were based on guidelines for Prevention and Early Management of Renal disease in Type 2...

Introduction: Lymphocytic hypophysitis is a rare autoimmune disease predominantly affecting females in the antepartum and postpartum period. It is characterized by destruction and lymphocytic infiltration of predominantly adenohypophysis with various degrees of hypopituitarism. Posteriour pituitary gland involvement is rare but has been reported. We report a case of a 32 year old lady who presented with diabetes insipidus and hypoadrenalism.Case: A 32 year old lady complai...

Objectives: Primary - Study of Correlation between Serum Osteoprotegerin, and Biomarkers of Bone Metabolism in Patients with treatment-naive Graves’ Disease (GD). Secondary- Serum level of Osteoprotegerin, TNF alfa and Biomarkers of Bone Metabolism in Patients 3 months after treatment of GD with methimazole (MMI).Material and Methods: A total of thirty-five treatment-naive newly diagnosed GD were recruited for the study, most of them were female. Al...

A male, born in 1957, with history of familial spinocerebellar ataxia, Type 2 diabetes (diagnosed in 1999), asthma, learning difficulties, chronic pancreatitis, recurrent falls, multiple low trauma fractures and osteoporosis was referred to Endocrinology Department in 2019. He sustained a right radial fracture at the age of 34 (1992), followed by comminuted right distal radius and Ulna styloid process fracture in 2002, Left and right Neck of Femur fractures in 2013 and 2014 re...

A 51 year old female patient presented in 2000 with a 7 month history of diarrhoea and weight loss. Bloods revealed hypokalaemia (1.9). Infection and malabsorption screen negative, but patient remained hypokalaemic despite maximum iv and oral replacement. No abnormality was found endoscopically. Fasting gut hormone profile showed raised Vasoactive Intestinal Polypeptide (VIP) >400 (NR <30). CT scan confirmed 5cm mass in body of pancreas, no metastatic disease. Response...

Background: Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy, resulting in death at a young age. Corticosteroids improve muscle function and slow disease progression. However long-term steroid therapy is a significant risk factor for osteoporosis.Aim: To assess the effect of oral bisphosphonate (risedronate) treatment on bone mineral density in a cohort of steroid-treated children with DMD.Method: Annual bone...

Introduction: Obesity is known to be associated with hypogonadotropic hypogonadism. Hypogonadism is an established risk factor for cardio vascular disease and Type 2 Diabetes Mellitus (T2DM). However there is paucity on the evidence on improvement in testosterone with bariatric surgery. We report two patients with normalisation of testosterone after bariatric surgery.Case Reports: Patient One 69 year old with BMI 40 and T2DM, hypertension, ischaemic hear...

Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women with an estimated prevalence of 6–8%. Women with PCOS have a known increased prevalence of prediabetes (30–40%), type 2 diabetes (T2DM 10%), and metabolic syndrome (40%). We determined the prevalence of recorded PCOS through a structured primary care based T2DM screening programme.Methodology: Eligibility criterion for a structured and systematic sc...

Pituitary carcinoma is rare and diagnosis requires demonstration of cerebrospinal and/or systemic metastasis. We present case of a 64-year-old lady who presented with widespread spinal metastasis from a pituitary adenoma diagnosed 36 years ago. Our patient presented in 1971 with visual failure, headache and oligomenorrhoea. Imaging confirmed pituitary macroadenoma and she underwent transcranial hypophysectomy. Histology revealed chromophobe adenoma. Post operatively her vision...