Endocrine Abstracts

Aggressive angiomyxoma (AA) is a rare mesenchymal tumor which is more common in females, occurring predominantly in the pelvi-perineal region. It tends to be locally aggressive with high recurrence after primary excision. The majority of these tumors are positive for oestrogen and progesterone receptors. Hence hormonal manipulation provides the possibility of effective treatment.Since 2005, we have been treating two female patients with AA medically (see...

A nineteen year old man was admitted by his GP with profound weight loss. He had avoided contact with primary care services as he feared doctors, but had been referred to an eating disorders clinic. He had a diet of exclusively snack food and had been losing weight for two years.On examination he was cachectic and pale with scanty body hair. His body mass index was 13 kg/m2, with a weight of 44 kg. He was clinically thyrotoxic, a small diffuse...

SOM230 is one of the long-acting somatostatin analogues, which has been developed for the treatment of neuroendocrine tumours. Recently we found that SOM230 inhibits the proliferation of human umbilical vein endothelial cells (HUVECs). The aim of this study is to further investigate its antiproliferative effect using adult human aortic endothelial cells (HAECs) and human dermal microvessel endothelial cells (HDMECs). The expression of SSTRs and the potential mechanism were obs...

Objective: To investigate a family with the unusual combination of Multiple Endocrine Neoplasia (MEN1) and the McCune-Albright syndrome for mutations of the MEN1 and GNAS1 genes. MEN1 is an autosomal dominant disorder characterised by parathyroid, pancreatic and pituitary tumours whereas the McCune-Albright syndrome is a sporadic disorder characterised by polyostotic fibrous dysplasia, skin pigmentation and hyperfunctioning endocrine tumours.<p class="abstext...

Objective: To audit the benefits of MIBG and familial screening in patients with a phaeochromocytoma or paraganglionoma.Results: 77 patients (male:female 34:43) have been seen within our hospitals since 1985. Further information has been located on 75. Patients had a median age of 44.3 years (range 19.4–81.2) and a median follow up of 12.0 months postoperatively (range 0–12 yrs). The adenoma was unilateral in 65 cases (86%, left 25, right 40) a...

PYY is secreted postprandially from the endocrine L-cells of the gastrointestinal tract. PYY3–36, the major circulating form of PYY, reduces food intake in humans and rodents via high affinity binding to the auto-inhibitory NPY receptor, Y2R, within the hypothalamic arcuate nucleus.Aims: To investigate (1) the effects of length of fast on the anorexigenic actions of PYY3–36; (2) the effects of early light phase administrat...

We have previously (Allehabadia et al., JCEM, 2001) reported better cure rates for patients treated with a single fixed dose of 370 MBq 131I compared with 185 MBq. We have since increased the standard dose of administered radioiodine to 600 MBq and re-audited our data in 1240 consecutive thyrotoxic patients. We aimed to compare the efficacy of the new dose regimen and to explore factors that might predict outcome. Patients were categorised in 3 diagnostic gro...

A 54-year-old female presented with one week of weakness, fatigue, headache, worsening constipation, and general malaise. Background history included long-standing type 1 diabetes (glutamic acid decarboxylase positive), on continuous subcutaneous insulin infusion, proliferative diabetic retinopathy, end-stage diabetic nephropathy on haemodialysis and subclinical hypothyroidism. Tertiary hyperparathyroidism was diagnosed (adjusted calcium 2.82 mmol/l, phosphate 1.42 mmol/l, par...

Aim To describe the early outcomes of carcinoid patients undergoing surgical heart valve replacement.Methods In a retrospective study, records of patients with symptomatic carcinoid heart disease referred for valve surgery between 2012 and 2021 were reviewed. The perioperative and early postoperative outcomes were analyzed.Results Thirteen patients, with a mean age of 64 years (range 55-79 years) underwent cardiac surgery for carci...

Introduction: Diagnosing acute abdominal presentations in pregnant women poses challenges due to the physiological and anatomical changes during pregnancy. The differential diagnosis is broad, encompassing both obstetric and non-obstetric causes. Among the rare occurrences, nonhemorrhagic adrenal infarction presents a particularly unusual scenario, lacking established guidelines for management and follow-up. We discuss a case of nonhemorrhagic adrenal infarcti...