Endocrine Abstracts

Background: Pheochromocytomas are tumors arising from chromaffin cells diagnosed in <1% of patient evaluated for hypertension.Methodology: A retrospective analysis of case records of those patients with histopathologically confirmed pheochromocytoma in our hospital from 1993–2006 (14 years) was conducted.Result: A total of 94 patients were diagnosed to have pheochromocytoma during this period. The median age at presentatio...

Aims: To calculate the sensitivity, specificity and positive predictive value of Parathyroid scintigraphy using Technetium-Sestamibi scan in the localization of parathyroid disease.Methods and material: This is a retrospective medical review of 161 patients who underwent the Parathyroid scintigraphy at our hospital in last six years. True positives were defined as patients with confirmed primary hyperparathyroidism (PHPT) on pathological examination. Tru...

Background: Insulinoma is an uncommon disease. The clinical profile of insulinomas among Indian patients is not well known.Aim of the study: To study the clinical characterstics, biochemical and radiological parameters,and treatment aspects of our adult patients with insulinomas.Methodology: We did a retrospective analysis of 18 patients with insulinoma treated from 1992 to 2004 in our institution. The data was analysed using a 11....

Aim: To analyse the clinical profile in patients with differentiated thyroid carcinoma.Materials & Methods: A retrospective analysis of case records of 232 patients who had under gone treatment for differentiated thyroid carcinoma from year 2000–2004 in Christian Medical College, Vellore was done and the intended data obtained using spss data.Results: A preoperative FNAC suggested thyroid neoplasm in 60%. Total thyroidecto...

Background: Education in diabetes is a fundamental component of self-management. Health care systems that have structured education from diagnosis have demonstrated improving trends in HbA1c. Within Wales, education for Children and Young People (CYP) was delivered informally and this deficiency was highlighted in the National Paediatric Diabetes Audit. While structured education is being delivered in some parts of the UK, there is no overarching programme covering the entire ...

Introduction: Various imaging modalities are used in the preoperative localization of insulinoma. CT is the modality that is in widespread use. Endoscopic ultrasound (EUS) allows the transducer to be placed in close proximity to the pancreas, thereby yielding images of higher quality, leading to accurate localization. An accurate preoperative localization results in a minimal invasive surgery and less occurrence of residual tumors, translating into a better clinical outcome. O...

Introduction: Craniopharyngiomas constitute 2–5% of all primary CNS neoplasms. We retrospectively analysed the case records of all patients with craniopharyngioma treated in our hospital from 1996 to 2006.Results: One hundred and twenty-seven patients were treated during this period. 65% were male and 35% were female. 50 patients (39%) were <15 yrs of age. The maximum clustering of cases was in the 6–15 yr age group (37%).<p class="abs...

Background: Studies have established a link between vitamin D deficiency and susceptibility to and severity of COVID-19. Our study aims to evaluate the role of vitamin D supplementation in intensive care units (ICU) in patients with COVID-19.Methods: We conducted a retrospective analysis of patients admitted to ICU in a large tertiary centre. Data on serum vitamin D concentration and supplementation, mortality, hospital and ICU stay, electrolyte replacem...

Background: Acidosis activates the hypothalamic-pituitary-adrenal (HPA) axis and induces glucocorticoid-mediated atrophy of skeletal muscle. The enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts inactive cortisone to active cortisol and modulates glucocorticoid signalling locally within skeletal muscle. Here, we address a gap in knowledge how acidosis affects 11β-HSD1 activity in human skeletal muscle cells.Methods: Quadrice...

Introduction: Congenital hyperinsulinism (CHI) is a rare disease, characterized by an unregulated insulin release, leading to hypoglycaemia. It is the most frequent cause of persistent and severe hypoglycaemia during the neonatal period and early childhood. Mutations in KATP < genes (ABCC8 and KCNJ11), together account for up to 70% of CHI. CHI can either be transient or persistent. Transient CHI tends to resolve spontaneously and is n...