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Endocrine Abstracts (2017) 49 GP38 | DOI: 10.1530/endoabs.49.GP38

ECE2017 Guided Posters Bone & Calcium Homeostasis 1 (10 abstracts)

Decreased trabecular bone score but not bone mineral density in patients with acromegaly and concurrent hypogonadism: cross-sectional study with healthy controls

Martin Kužma 1 , Dušan Pavai 2 , Ivana Ságová 3 , Zdenko Killinger 1 , Peter Jackuliak 1 , Anton Vaňuga 2 , Peter Vaňuga 2 & Juraj Payer 1

1Comenius University Faculty of Medicine, Fifth Department of Internal Medicine, University Hospital Bratislava, Bratislava, Slovakia; 2National Institute of Endocrinology and Diabetology, Lubochna, Slovakia; 3Comenius University Jessenius Faculty of Medicine, First Department of Internal Medicine, University Hospital, Martin, Slovakia.

Introduction: Acromegaly is associated with higher prevalence of vertebral fractures (VFx) and bone microarchitecture potentially play a role in fracture development. Trabecular bone score (TBS), a novel indicator of bone microstructure could provide additional information.

Objectives: Assessment of BMD, TBS and bone turnover markers (BTM) in acromegaly patients in comparison to healthy controls with regard to gender, hypogonadism and disease activity.

Patients and methods: A cross-sectional study of acromegaly patients with age-, gender- and BMI-matched healthy controls was conducted. Study group consisted from all acromegaly patients (regardless age, gender, disease duration or activity) which came for follow-up visit during period 6/2016 – 12/2016 and the control group consisted of healthy subjects. In all subjects a single measurements of all pituitary axis hormones levels, BTM, BMD of total hip (TH) and lumbar spine (LS) and TBS was performed. N-terminal type 1 procollagen (P1NP) - marker of bone formation and C-terminal telopeptide (CTx) –marker of bone resorption were analyzed.

Results: Thirty Seven acromegaly patients (12 males/25 females with mean age 56.7 years, mean BMI 29.8 kg/m2) and 27 of control group subjects (seven males/20 females with mean age 59.5 years, mean BMI 30.9 kg/m2) were included. TBS was significantly lower in patients in comparison to controls (1.16 vs 1.22; P<0.05), but no BMD and BTM difference was observed. Hypogonadal patients had lower TBS in comparison to patients without hypogonadism (TBS 1.13 vs 1.20; P<0.05) and no BMD difference. BTM were increased in hypogonadal patients (CTx 0.67 vs 0.38 ng/ml; P1NP 75.5 vs 47.5 ng/ml; both P<0.05). No difference in TBS, LS BMD and BTM with regard to gender was observed.

Conclusion: This study indicates that patients with acromegaly, especially those with hypogonadism, despite unchanged BMD, may have impaired trabecular bone microstructure, which can lead to increased prevalence of fractures.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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