Endocrine Abstracts

Objective: To evaluate the GRI and its association with other CGM metrics after initiation of automated insulin delivery (AID) system in adults with type 1 diabetes (awT1D).Methods: Up to 90 days of CGM data before and after initiation of an AID system from 185 awT1D were collected. GRI with hypoglycemia and hyperglycemia components and other CGM metrics were calculated using cgmanalysis R software and analyzed for 24-hour, nighttime, and daytime. GRI va...

Background: In polycystic ovary syndrome (PCOS), in response to stimulation by luteinizing hormone (LH), the ovarian theca cell synthesizes androgens. However, associations of serum androgen levels with metabolic parameters yet to be determined. We aimed to investigate these associations.Methods: We retrospectively evaluated our outpatient admission records for PCOS, hirsutism, oligomenorrhea, or secondary amenorrhea. PCOS diagnosis was made after exclud...

Background: Hyperprolactinemia is frequently reported with polycystic ovary syndrome (PCOS). However, there is a controversy whether they share a common mechanism or have cause–result relationship or just are coincidental. The objective of the present study was to identify the cause of hyperprolactinemia in patients with PCOS.Methods: We retrospectively evaluated our outpatient admission records for PCOS, hirsutism, oligomenorrhea, or secondary amen...

Background: Osteocalcin (Ost) is an osteoblast derived protein locally acting on bone formation. Ost could also have a role in regulation of glucose and fat metabolism. It has been shown that Ost can directly stimulate proliferation of β cells and have effect on secreting insulin, and can act on insulin sensitivity by cytokines. It was not fully investigated in gestational diabetes mellitus. The aim of our study was to investigate osteocalcin in Turkish gestational diabet...

One of the main problems encountered with increased levels of serum PTH is decrease in bone mineral density in the long term. Secondary hyperparathyroidism due to vitamin D deficiency leads to mineralization disorders of the bones, low bone mineral density, osteoporosis and ultimately an increased risk of bone fracture in adults. In this study, we aimed to determine the reasons of secondary hyperparathyroidism for bone mineral density.One hundred and thi...

Background: There is some evidence suggesting an interaction between renin-angiotensin-aldosterone system and parathyroid hormone (PTH). Decreased aldosterone levels after parathyroidectomy have been reported in patients with primary hyperparathyroidism (PHPT). Recently, most of the diagnosed patients with PHPT are mild or asymptomatic. Our aim was to investigate plasma aldosterone and renin concentrations in patients with asymptomatic PHPT.Methods: Thir...

In this study, we aimed to investigate the causes of elevated PTH levels in postmenopausal women without the use of drugs that may affect of PTH levels and without concomitant diseases.A total of 156 postmenopausal women, aged ≥ 50 years, had no menstruation for at least 2 years and had no disease known to affect calcium metabolism were considered. Education, occupation, average duration of exposure to sunlight per day in summer and winter, consump...

Objective: Cushing’s syndrome (CS) is related to diabetes mellitus, dyslipidaemia, hypertension, and obesity, which lead to cardiovascular disease (CVD). CVD is the major cause of mortality and morbidity in CS. The aim of our study was to investigate CVD risk markers, such as asymmetric dimethylarginine (ADMA), lipoprotein-associated phospholipase A2 (Lp-PLA2), highly sensitive C-reactive protein (hsCRP), homocysteine, lipid levels, ankle-brachial index (ABI), and carotid...

Introduction: 46 XX male syndrome generally presented as hypogonadotrophic hypogonadism.Case report: A 39-year-old man was referred to our clinic with a pituitary mass. He had a history of pituitary adenoma of 45×28×40 mm size which was found after his admission with right-sided vision loss at 2006. The hormonal analyses showed hypogonadotrophic hypogonadism without any excess hormone levels. A transcranial pituitary adenomectomy was performed....

Introduction: Werner syndrome (WS) is an autosomal recessive disease characterized by premature aging, skin changes, gray hair, alopecia, muscle atrophy, osteoporosis, and cataracts and has a high frequency of association with rare neoplasms. In addition, some endocrinological abnormalities were manifested in this rare disease, such as hypogonadism, diabetes mellitus, hyperlipidemia. Atrophic changes of organs and systems such as skin, brain and genital organs were reported. H...