Endocrine Abstracts

Introduction: Hypogonadotropic hypogonadism is the cause of sexual deficiency, sometimes difficult to differentiate from constitutional growth delay (CGD).Clinical case: A 19-year-old male consulting endocrinology for delayed puberty. Pointed to, at 13 years of age, as having had CGD. His medical report include a viral meningitis at 8 years of age and anosmia since 3 years of age. He expressed lack of sexual desire and concern about the size of his genit...

Introduction: Obesity and its comorbidities, specially type 2 diabetes (T2D), are a major public health problem. The disappointing result of dietary treatment and the scarce of drugs have led to increased bariatric surgery (BS) as the most efficient therapeutic option. However, not all obese patients with T2D who undergo BS achieve diabetes remission.Objective: To develop a genetic scoring system for predicting T2D remission following BS. 2) To compare o...

Survival of most species relies on the fact that small populations of endocrine neurons located in the hypothalamus determine critical functions such as reproduction, growth, and metabolism. These neurons are so finely regulated that their functions have been conserved across evolution; nonetheless, the mechanisms underlying these regulatory features remain hazy. Indeed, research efforts have been hindered by the complexity and inaccessibility of the hypothalamic-pituitary sys...

Introduction: Surgery is the treatment of choice for non-functioning pituitary adenomas (NFPA), but remnants are frequently observed. Management of these remnants include observation (OBS), radiotherapy (RT) and/or dopamine agonist (DA) therapy. In this study, we evaluate the progression-free survival (PFS) of NFPA with postoperative remnant and the potential factors involved.Methods: We performed a single-center ambispective study of a cohort of 72 pati...

Purpose: To assess the impact of serum corrected calcium (CorrCa), magnesium (Mg) and phosphorus (P) levels at hospital admission on SARS-CoV-2 infection outcome.Methods: In this retrospective study, all adult patients with laboratory-confirmed COVID-19 hospitalized in Hospital Universitario Puerta de Hierro Madadahonda during 2020 were included. Demographic, clinical and laboratory data were registered and related to the prognosis of the disease. Poor o...

Many of the functions of ovarian steroids in regulating embryo-implantation occur through the actions of cytokines and growth factors on the uterus. One such cytokine, Leukaemia Inhibitory factor (LIF), is critical for implantation in a range of mammalian species. LIF is expressed transiently in the murine glandular uterine epithelium (GE) on day 1 and then day 4 of pregnancy (day of implantation) induced by estrogen. Female mice lacking a functional LIF gene cannot support em...

Graves’ disease is one of the multiple autoimmune diseases that have been reported in HIV-infected patients. With the upsurge of highly active anti-retroviral therapy (HAART) the incidence of autoimmune diseases in HIV-infected patients is increasing, especially after immune reconstitution. We present a male, 51-year-old, who started complaining with anxiety, sudoresis and palpitations. The laboratory workout revealed hyperthyroidism: TSH <0.02 μU/ml (0.46–4...

Aim: Obesity was shown to be related to global cognitive decline, being especially altered the executive function and the information processing speed. Bariatric surgery (BS) is an effective means of weight reduction in severely obese patients and correlates with improvements in neurocognition. The mechanisms underlying these improvements are not fully elucidated.Material and Methods: Prospective, observational study, including consecutive patients that ...

Introduction: Poems Syndrome is a rare multisystem disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma-proliferative disorder and skin changes, among other features. Literature describes endocrine abnormalities at least in 93% of patients with Poems Syndrome during the diagnosis as well as during the follow-up. The most common deficiencies ranked by their frequency are hypogonadism, hyperprolactinemia, hypothyroidism, abnormal glucose meta...

Introduction: Grave’s disease (GD) is an autoimmune disease characterized by the development of thyroid-stimulating hormone (TSH) receptor antibodies that have a stimulating effect on the thyroid gland. There is a rare but non-incidental and well-documented association between GD and thymic hyperplasia (TH). Nonetheless, this association is often underdiagnosed in routine clinical practice and the mechanisms behind this association have yet to be thoroughly elucidated. Th...