Endocrine Abstracts

Background and Aims: The gut microbiome has been shown to differ between healthy individuals and those with diabetes and even in women with gestational diabetes mellitus (GDM). This raises the question of its role in postprandial glycemic response (PPGR). We aimed to evaluate the impact of microbiome features in PPGR in women with GDM and healthy pregnant women.Methods: We obtained stool samples for 96 pregnant women (65 GDM, 31 control), previously recr...

Based on the medical records of 311 patients with medullary thyroid carcinoma (MTC) treated in the period 1979–2018, using the Kaplan-Meier method, it was found that the sporadic form and male patients are negative predictors of disease. Other is essential for patients with sporadic form of MTC, because sex has no prognostic value in patients with hereditary forms of the disease. The presence of metastases in regional lymph nodes or distant metastases is a poor prognosti...

Aim: To evaluate the adipocins content in the blood with IGT.Materials and methods: One hundred and one patients with IGT were examined (86 women and 15 men) middle-aged 62.1±1.2 years old. The control group included 16 patients (eight women and eight men) middle-aged 22.6±0.6 years old. The anthropometric indications (IMB, WC, and WC/TC), HOMA-IR, insulin, CRP, resistin, leptin, and omentin levels were investigated.Resul...

Introduction: The reccurence rate after successful neurosurgery for patients with Cushing’s disease (CD) varies between 10% and 65%. It is shown earlier that some features are associated with the probability of recurrence, yet no rules were elaborated how to analyse the set of variables.Materials and methods: The retrospective study was based on 219 cases of CD (32 men, 187 women) with a disease duration ranged from 4 months to 22 years, who underwe...

Thyroid dermopathy or pretibial myxedema (PTM) is a rare extrathyroidal manifestation of Graves’ disease with diverse presentations. Therefore, information on the clinical data of PTM patients is scarce. In this study, we aimed to evaluate the clinical features of patients with thyroid dermopathy and Graves’ disease. A total of 43 patients with pathologically confirmed PTM were retrospectively recruited. According to the diagnosis, the clinical data and laboratory fi...

Somatotropin (GH) and IGF1 realise their influence on the system of intracellular metabolism and a number of important biochemical lymphocytes reactions through the receptor apparatus. It is allows to use the peripheral blood lymphocytes as the investigations object of intracellular metabolism disorders in acromegaly.Aim: To study the NAD- and NADP-dependent dehydrogenases activity in blood lymphocytes in active acromegaly patients.<p class="abstext"...

Aim: To evaluate leptin and other adipocins content in the blood with type 2 diabetes.Materials and methods: Eighty six patients with type 2 diabetes were examined (59 women and 27 men) middle-aged 58.6±1.04 years old. The control group included 16 patients (eight women and eight men) middle-aged 22.6±0.6 years old. The HOMA-IR, insulin, adiponectin, resistin, leptin, and omentin levels were investigated.Results: In patie...

Introduction: Graves’ disease (GD) is organ-specific autoimmune-inflammatory disorder characterized by a complex pathogenesis. The inflammatory process is dominated by an imbalance of the antioxidant-oxidant mechanism, increased production of reactive oxygen species (ROS), which can potentiate the cytotoxicity of neutrophils and sustain the autoimmune process and perpetuate the disease. Aim: to study the level of ROS synthesis by peripheral blood neutrophils in patients w...

Background: Oxidative stress is involved in the pathogenesis of Graves hyperthyroidism (GH) and a disbalance of the cell redox state is associated with thyroid hyperfunction and the reccurence of the disease. Aim: To study the level of reactive oxygen species (ROS) and NAD(P)-dependent dehydrogenases of peripheral blood neutrophils in patients with compensated and relapse GH ongoing thiamazole. Materials and Methods: The study incl...

Background: Increased production of reactive oxygen species (ROS) and oxidative stress play a significant role in the initiation and persistence of the autoimmune process in Graves’ disease (GD)Aim: To study the ROS level of peripheral blood monocytes in patients with GD after radioactive iodine (RAI). Materials and Methods: The study included 48 patients with a confirmed diagnosis of GD, from 18 to 65 years (mean 46.42 &pm; 1...