Endocrine Abstracts

Objective: Neurosteroids, a unique hormone group, are recognized for their impact on cognitive processes. The primary objective is to assess the correlation between cognitive function and NS levels in cases of Cushing’s disease and a control group of nonfunctional pituitary adenoma (NFPA).Design: The study comprised 26 individuals diagnosed with Cushing’s disease (CDG), while a control group (CG) consisted of 14 age-gender matched participants ...

Introductıon: Rathke’s cleft cysts (RCCs) are benign lesions originating from the epithelial remnants of Rathke’s pouch with a peak incidence at 30–50 years of age. It is detected at a rate of 13–33% in several autopsy series. RCC is usually asymptomatic and diagnosed incidentally. In symptomatic cases, common symptoms are headache, visual disturbance, and symptoms related to hypopituitarism.Case: A 28-year-old male patient prese...

Neurosteroids refer to hormones with a steroid structure and, their synthesis pathways are identical to those of traditional steroids. However, neurosteroids are generated denovo in the central and peripheral nervous systems and utilize cell surface receptors. Few animal studies indicated synthesis of NS in pituitary. Presence of neurosteroids in human pituitary adenomas(PAs) has yet to be assessed. This is preliminary data of an ongoing study. Seventyseven specimens from huma...

Background: Hypophysitis is a rare group of disease characterized with infla mmation of the pituitary gland. Rarity of the disease obviates development of a treatment strategy. We aimed to present the nationwide data of the demographics, clinical and radiological characteristics, treatment modalities and responses of the patients diagnosed with hypophysitis in a retrospective manner.Methods: The endocrinology clinics all over the country were invited to ...

Objective: Aim of the study was to investigate the spectrum and prevelance of goiter and thyroidal diseases by ultrasonography in moderately iodine deficient area.The MELEN study is a prospectively designed survey on the prevalence of cardio metabolic risk factors and thyroid diseases in Turkish adults. A total of 2298 subjects with a mean age of 50 (age range 18–92) were interviewed. Thyroid ultrasonography was performed and interpreted by the same...

Objective: Hypopituitary patients receiving convensional hormone substitution, but without growth hormone (GH) replacement, have an increased mortality from cardiovascular disease. The aim of the present study was to assess the heart rate variability(HRV) in hypopituitary patients with severe GH deficiency.Material and method: Thirty-five patients (20 women, 15 men, aged 23-75 years) with severe GH deficiency, all of 35 patients with low insulin-like gro...

Objective: We aimed to evaluate the frequency of malignancy in patients with follicular lesion or follicular neoplasia in cytological examination.Method: About 29 patients who had follicular neoplasia or follicular lesion in cytological examination after ultrasound guided thyroid fine needle aspiration biopsy (FNAB) were included in the study. Histopathologic results were evaluated after thyroidectomy in all patients.Results: There...

Objective: Fine needle aspiration biopsy (FNAB) is a reliable and safe method to distinguish benign and malignant thyroid nodules. FNAB has two major limitations: nondiagnostic and suspicious cytology results. There is uncertainty about clinical approach to the nondiagnostic FNAB in thyroid nodules. Our aim was to evaluate the ratio and reasons of nondiagnostic results, and the ratio of malignancy in these nodules.Method: About 2082 patients and 3404 nod...

Aim: The present study was designed to examine the relationship between adiponectin gene (T45G in exon 2) polymorphism and clinical and hormonal characteristics in women with polycystic ovary syndrome (PCOS).Materials and methods: Ninety-six patients with PCOS and 93 healthy subjects were included in the study. Serum levels of sex steroids, insulin and adiponectin levels were measured. Insulin resistance was evaluated by homeostasis model assessment (HOM...

The pathologist cannot easily decide some thyroid fine-needle aspiration biopsy (FNA) into the benign, suspicious, or malignity and this condition are reported as ‘atypia of undetermined significance’ (AUS) or ‘follicular lesion of undetermined significance’ in the Bethesda system. Diagnosis of AUS of a thyroid nodule is leaved an endocrinologist as well as the patients in a difficult situation. However, the risk of malignancy at AUS is ~5–15%. Our aim...