Endocrine Abstracts

Introduction: Hungry bone syndrome (HBS) is a rare condition that can appear after surgery for hyperparathyroidism, characterized by hypocalcemia, hypophosphatemia, low calciuria, especially in patients with severe primary hyperparathyroidism, bone lesions and elevated alkaline phosphatase. We present a case of severe persistent hypocalcemia after resection of a giant parathyroid adenoma in a patient with concurrent osteoblastic bone metastasis from prostate cancer.<p clas...

Introduction: Multiple endocrine neoplasia type 2A is an autosomal dominant disorder which is characterized by the occurrence of medullary thyroid carcinoma in association with pheochromocytoma and parathyroid tumors.Case report: We present the case of a 64-year-old woman, with familial history of thyroid carcinoma, renal lithiasis and personal history of right nephrectomy for renal lithiasis, who presented for the investigation of a left lateral cervica...

10% of patients with adrenal tumours have bilateral lesion.Objective: To evaluate clinical, imagistic and hormonal characteristics of bilateral adrenal tumours.Design and mehods: Retrospective series of 150 consecutive patients (104F, 46M) with bilateral adrenal tumours with maximal diameter of at least 1 cm, evaluated from 2001 to 2015 in a tertiary endocrinology clinic with clinical, hormonal and imagistic methods.<p class="a...

Acromegaloidism includes clinical features of acromegaly with GH and IGF1 normal levels at baseline and dynamic, without findings of extrapituitary or pituitary tumour. It has been associated with various conditions without a definite pattern. The aim was to evaluate whether there are differences in some hormonal pituitary axis from acromegaloid subjects with respect to acromegalic and healthy subjects. We designed a comparative, multicenter, case–control study in three h...

Acromegaloidism is a very rare entity (have been 54 cases reported worldwide) that presents with clinical acromegaly and normal somatotropic axis, without findings of pituitary or extrapituitary tumour. Its origin has not been clearly established, although it is associated with several pathophysiological conditions. The local ethics committee approved to perform an observational and multicenter study in three hospitals from a region with approximately 800 000 people over 18 ye...

Background: Secondary hyperparathyroidism (HPT) is a common complication seen in 12-54% of end stage renal disease patients (ESRD), owing to the calcium and phosphorus perturbations in these patients1. Successful kidney transplantation (KT) is expected to correct these abnormalities, however, it is not uncommon for hyperparathyroidism to persists post-transplantation 2,4,5,22. Persistent hyperparathyroidism is associated with significant mortality and mor...

Introduction: In Mexico there is scant literature about medical management and its response in patients with acromegaly. Octreotide LAR at a dosage of 20 mg weekly is considered as first line treatment in patients who failed to surgery or who are not candidates to surgical treatment. The goal of this initial dosage is to reach GH levels below 1.0 ng/ml and insuline like factor type 1 (IGF1) levels within range for age and gender. The objective of this study is to determine the...

Background: Thyroglobulin (Tg) is a promising biomarker for monitoring iodine nutrition in children and pregnant women. The determination of Tg in dried blood spots (DBS) offers many logistical advantages, simplifying the collection, transport, and storage of samples. The present study aimed to validate an ELISA assay for Tg determination in newborns.Methods: Tg-DBS samples were measured in 196 newborns born from healthy pregnant women. The different cri...

Nutritional status has an important effect on the progression of any disease, not only in hospitalized patients, even more in ambulatory patient of primary care. Although there are many systems of evaluating nutritional status, they are costly and subject to variability amongst individuals. The Medicine Laboratory can correctly perform a nutritional evaluation in a quick an efficient manner.Objective: Analyze the nutritional status by CONUT nutritional e...

Background: Acromegaly results from excess growth hormone (GH) secretion by a pituitary adenoma in 95% of the cases. Discordant acromegaly is defined by the elevation of GH with normal levels of insulin-like growth factor type 1 (IGF-1) or normal levels of GH associated with an elevation of IGF-1. Its an important situation in the follow-up period of patients with acromegaly because there is little information about patient treatment, comorbidities and follow-up. The objective...