Endocrine Abstracts

Background: Acromegaly is a rare endocrine disorder due to growth hormone excess attributed to a pituitary tumor, in most cases. Epidemiological data of acromegaly are derived from national tumor registries or population studies while there are no published data in the Greek population except for a few small studies regarding treatment outcome.Methods: We carried out a retrospective ongoing observational study to determine the epidemiology, presentation ...

Acromegaly is a rare and insidious endocrine disease, with increased morbidity and mortality mainly due to delayed diagnosis and inadequate control. There are many population studies assessing the epidemiology of acromegaly in Europe while in Greece, there are no published data except for a few small studies regarding treatment outcome.Aim: To determine the epidemiology, presentation and outcome in patients with acromegaly in Crete, Greece.<p class="...

Neuroendocrine tumors (NETs) represent a very heterogenous group of neoplasms, comprising approximately 2% of all malignant tumors of gastroenteropancreatic system. Although they are characterized by a relatively slow tumor growth, they have a malignant potential and, in fact, most of them are diagnosed when distant metastases have been developed. NETs, when functioning, are causing symptoms related not only to the tumour mass itself, but also to the specific hormonal peptide ...

Different diets have been used clinically and/or have been rigorously assessed in the context of clinical trials in the past several years. Relative efficacy in terms of weight loss and improvement of cardiovascular outcomes will be presented. In addition, recent data have emerged on the role of leptin in mediating the neuroendocrine response to long-term caloric derivation and will also be presented along with novel data on leptin resistance. Leptin, alone or in combination w...

My research focuses on the interplay of brain and adipose tissue and the elucidation of the physiology, diagnostic, and therapeutic utility of adipokines and myokines. We defined the central role these compounds play in normal physiology and pathophysiology of several diseases in humans, with the notion that such investigations will eventually lead to new treatments for metabolic and cardiovascular disease. We have also studied in-depth the role of leptin in the brain, definin...

Introduction/Aim: MIDD (maternally inherited diabetes and deafness) and MELAS (mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes) are rare, maternally inherited, multisystem disorders caused by mitochondrial DNA mutations. We present the case of a patient with mitochondrial diabetes and discuss the diagnostic challenges.Case presentation: A 25-year-old female patient with a 7-year history of diabetes mellitus (DM) and suboptimal glyc...

Aim: Current guidelines for type 1 diabetes mellitus (DM1) suggest a therapeutic goal for glycosylated hemoglobin (A1c) of < 7.0% in adults and < 7.5% in children and adolescents, while emphasizing the importance of managing dyslipidemia. We aimed to record the achievement of therapeutic goals in DM1 patients followed-up in a Greek tertiary center.Methods: Data were included from DM1 patients who had visited the Department at least once in the pr...

Introduction: Current guidelines emphasize the important role of Continuous Glucose Monitoring (CGM) for type 1 diabetes mellitus (T1DM) management. The aim of the GlucoseML study is the development of a mobile health system for T1DM self-management based on CGM data, physical activity, food intake and insulin dosage. We herein present the development and evaluation of a univariate Autoregressive Moving Average (ARMA) prediction model of interstitial glucose concentration for ...

Gestational diabetes affect about 5% of all pregnancies and is associated with increased risk for mother and fetus. It has been shown to be associated with increased risk for preeclampsia, postpartal bleeding, and cesarean section rate as well as intrauterine fetal death, macrosomia, shoulder dystocia, and neonatal hypoglycaemia. Several studies have shown the beneficial effect of tight blood glucose control even in mild gestational diabetes. Diet and insulin treatment are the...

A 36 year old man was referred to the Endocrine clinic from his GP practice due to an incidental finding of high Testosterone (44.3 nmol/l). He is an actor who has been under a private Trichologist for a number of years, and had been on Finasteride and topical Mixonidil. Under the Trichologist he has had his Testosterone levels periodically monitored, which had been persistently elevated since at least 2018 (39-44 nmol/l). The patient was otherwise well. He has Type 1 Diabetes...