Endocrine Abstracts

Background: Cardiovascular disease accounts for about one-third of all premature deaths (ie, age <70) in Cuba. Yet, the relevance of major risk factors, including diabetes, systolic blood pressure (SBP), and body-mass index (BMI), to cardiovascular mortality in this population remains unclear.Methods: In 1996–2002, 146,556 adults were recruited from the general population in five areas of Cuba. Participants were interviewed, measured (height, we...

Purpose: To determine the association between clinical indicators of metabolic state and cardiovascular, infectious and metabolic complications during or after elective surgery in patients with type 2 diabetes mellitus (T2DM) regardless of their treatment scheme.Methods: Prospective observational study. Patients with T2DM, ages 20–80 years, scheduled for elective surgery were evaluated with office BP, BMI, Hb1Ac, fasting glucose, fibrinogen, total c...

Introduction: While there is no consensus about population screening for hypothyroidism there is compelling evidence to support case-finding for hypothyroidism in those with autoinmune disease, such as type 1 diabetic patients. The present study has been made to estimate the prevalence of thyroid dysfunction in type 2 diabetic patients. In the British Whickham survey 9.3% of women and 1.2% of men had serum TSH values over 10 μIU/ml. The Colorado thyroid disease prevalence...

Introduction: Clinical observational studies have reported the persistence of a high cardiovascular risk in patients with cured Cushing’s syndrome (CCS) compared with controls of the same age, gender and BMI. It is still at debated whether this is due to the persistence of comorbidities, hormone deficiencies or chronic changes induced by hypercortisolism. The aim of this translational approach was to investigate the interplay in CCS of the cardiovascular disease in vivo a...

The USMBDPCP is unique that it is the first study to consider the whole US- Mexico Border as one epidemiological unit. The project goal is to reduce the burden of diabetes among persons with type 2 diabetes living in the U.S.-Mexico border region. I Development of a Prevalence Study and identification of risk factors. II Implementation an intervention pilot study for diabetes prevention and control.Phase IThe diabetes prevalence su...

Background: Patients who require levothyroxine (LT4) supplementation after total thyroidectomy often have difficulty achieving target TSH levels. Several studies have attempted to develop a dosing schedule considering different factors such as age, gender, weight, or body mass index (BMI) as potential determinants of the correct dose of LT4. The objective of this study is to determine if a scheme that uses the percentage of body fat (%BF) measured by CUN-BAE is more accurate t...

Introduction: Pseudohypoparathyroidism (PHP) is a heterogeneous group of endocrine disorders characterized by target-organ resistance to the action of PTH, manifesting with hypocalcemia, hyperphosphatemia, and increased serum concentrations of PTH. PTH receptor couples with the stimulatory G protein (Gsα), leading to cAMP formation. Most cases of PHP are caused by heterozygous inactivating mutations in the GNAS gene, encoding Gs〈 (PHP type 1A) or methylatio...

Growth hormone (GH) is involved in body growth and metabolism. This hormone is used for the treatment of various clinical conditions and is administrated subcutaneously once daily or 3 times a week. The chronic use of GH has side effects; among them, the increase in tumor incidence. GH activates pathways related with oncogenesis not only by the activation of its specific receptor, but also by transactivation and regulation of the expression of the epidermal growth factor recep...

Given the importance of transcriptional regulation in metabolic control, we investigated the role of nuclear receptor co-factors in the liver, a key organ in energy homeostasis. Here we show in mice that the expression of receptor interacting protein 140 (RIP140) in the liver is induced in catabolic states like fasting and cancer cachexia. In contrast, chronic high fat diet feeding reduced RIP140 mRNA levels in the liver. Increased hepatic RIP140 in catabolic conditions was as...

Background: Incidental discovery of an adrenal mass (AM) presents a common finding in patients with a history of extraadrenal malignant tumour. Discerning malignancy in AM is based on radiology (Rx) and scintigraphic (Sx) criteria, and finally fine-needle aspiration biopsy (FNA) of the tissue.Objective: Determine the concordance of Rx and Sx techniques in patients with an AM and previous oncologic history.Materials and methods: We ...