Endocrine Abstracts

Background and aim: Early glycemic control and weight reduction in diabetes has been associated with prevention of progression of β-cell dysfunction and reduction in diabetes-related complications. Digital therapeutics (DTx) platforms can provide evidence-based therapeutic interventions to improve glycemic control using sustainable behavior change. This study aims at assessing the real-world effectiveness of the Fitterfly Diabetes program in improving glycemic control and...

Aim: To evaluate current practices relating to diagnosis and treatment of congenital hypothyroidism (CHT) in Aneurin Bevan University Health Board (ABUHB) compared to national guidelines and the use of radioisotope scanning in improving etiological diagnosis.Method: This service evaluation used a database of paediatric hypothyroid patients in ABUHB. Only children with CHT were included and any children born before January 2014 were excluded. 30 children ...

Background: An endocrine disruptor is an exogenous chemical or mixture of chemicals that interfere with any aspect of hormone action. It can interfere with the body’s endocrine system and produce adverse cardiovascular, neurological, developmental, reproductive, and metabolic effects in humans. This study aims to evaluate the knowledge, attitude, and practices (KAP) of the medical students regarding the exposure, usage, and long-term harmful effects of Endocrine Disrupt...

Background: Conventional methods of one-way teaching may not involve the integration of clinical skills and may become more inefficient and passive [1]. During the COVID-19 pandemic, limited patient interaction and shift to online lectures greatly reduced the clinical exposure and opportunity of developing interpersonal skills for junior medical students. In this study, we hosted online webinars with case-based teaching for medical students so that they can amalgamate clinical...

Genitalia appear larger and swollen in all neonates due to the circulating maternal hormones and this subsides spontaneously over few weeks or months. Additionally, general growth of the rest of the body outpaces any growth of the genitalia during childhood, resulting in apparent reduction in the size of the genitalia comparatively. There are high levels of circulating androgens in children with CAH until the commencement of medical replacement therapy (MRT). It is universally...

We describe a 82 year old patient with background history of thyrotoxicosis (had total thyroidectomy), primary hyperparathyroidism (had parathyroidectomy 12 years back at another hospital – two glands removed). She was on L-thyroxine, alfacalcidiol 1 μg/day and CaCO3 500 mg BD. She remained stable for 7 years on this cocktail. In February 2017, she was admitted with acute confusion and was found to have adjusted ca level of 4.57 with AKI, no...

: 39Y old male who was originally treated as child with CAH secondary to 21-Hydroxylase deficiency and was put on glucocorticoids and mineralocorticoids from first week of life due to salt wasting crises. He has had very high 17-OH progesterone and adrenal androgen due to noncompliance. He developed polycythemia secondary to androgen excess, resulted in venesection. Haematologist have investigated the mutation and EPO measurement and he felt that this was probably secondary po...

This is the case 32y old Asian lady, who first presented to her GP in October 2013 with weight loss, palpitations and fatigue and found to have overactive thyroid. She has not experienced any neck pain or systemic illness. She has some neck tenderness but not goitre or any extra-thyroidal manifestation of Graves’ disease, hence the thyroid nucleotide scan was requested. His scan was consistent with thyroiditis. By January 2014 her thyroid function test normalized with TSH...

Background: PCOS women usually have metabolic disturbances particularly insulin resistance. Previous studies suggest that vitamin D deficiency may contribute to the development of insulin resistance. Our aim is to study the effect of vitamin D supplementation on clinical and biochemical parameters in vitamin D deficient PCOS women.Methods: At baseline, 50 PCOS women were enrolled (37 vitamin D deficiency and 13 vitamin D sufficiency). Thirty-seven PCOS w...

Background: 3D-modelling is a computer-generated simulation technique that allows the users to interact with a three-dimensional environment and provide an immersive experience to understand minuscule details which becomes especially important when understanding the anatomical relations of endocrinology organs. During the COVID-19 pandemic, medical lectures were shifted to online mode which diminished the opportunity of cadaveric-based teaching that is routinely done for first...