Endocrine Abstracts

Background: Obesity is strongly associated with a state of chronic low grade systemic inflammation and insulin resistance (IR). IR at the molecular level may be defined as a diminished activation of the metabolic phosphatidylinositol-3-kinase (PI3K)/Akt pathway of insulin. On the other hand, inflammatory response may be activated by NF-κB. Subject with obesity have elevated plasma levels of saturated fatty acids, such as palmitic acid (PA), which triggers insulin and infl...

Background: Obesity is strongly associated with insulin resistance (IR). IR at the molecular level may be defined as a diminished activation of PI3K/Akt signaling and its related molecules (IRS-1/Akt/AS160) as well as reduced glucose uptake. Subjects with obesity have elevated plasma levels of saturated fatty acids, such as palmitic acid (PA), which triggers insulin signaling disruption in vivo and in vitro. Oregano (Origanum vulgare L.) is a plant u...

Context: Glucocorticoids (GC) mediate some of the adverse health-related consequences of circadian misalignment, such occurs in shift workers who have an increased cardio-metabolic, immune and cancer risk. Investigating the effect of circadian cortisol exposure in patients with GC excess and defect is crucial. In a therapeutic perspective large attention has been given to the total daily GC exposure, much less to the timing-of-the-day relative exposure. Clock genes are essenti...

Objective: To determine the prevalence of hypothyroidism among elderly subjects living in Karu village in the Federal Capital Territory.Methods: A community-based cross-sectional study involving 308 elderly subjects. A structured interview administered questionnaire was used for relevant data collection including biodata, clinical signs, and symptoms of hypothyroidism. Weight, height, waist circumference, presence and es...

Background: Coronavirus pandemic had pushed both doctors and patients to adapt to teleconsultation for routine consultations in management of type 2 diabetes (T2DM). Telemedicine is believed to be an effective resource in health access but its experience to the patient and its outcome of management are not well understood in semi urban and village population of India. Thus, this study aims to assess the experiences and outcomes of T2DM management by tele-consultation in these ...

At present there are no unified diagnostic criteria for subclinical hypercortisolism (SH) in patients with adrenal incidentalomas (AI). Recently it has been proposed that an age and gender specific DHEAS ratio (calculated by dividing DHEAS by the lower limit of the respective reference range) has a significant diagnostic value in detection of SH.The aim was to evaluate the value of DHEAS as a diagnostic tool for SH. Retrospectively we evaluated 140 AI pa...

Introduction: The prevalence of adrenal incidentalomas (AI) and renal cysts increase with age. Depending on the study population age and sex, on average, both are prevalent with about 8 to 10% in subjects older than 50 years of age.Aim: We aimed to investigate the co-occurrence of AI and simple renal cysts.Methods: Our study included 970 subjects, 494 with AI – all evaluated in single centre, and 476 control group (CG) patien...

Introduction: The National Osteoporosis Guideline Group (NOGG) recommends determine BMD in patients who present an intermediate risk of osteoporotic fracture using the FRAX® tool, follow-up for low risk, and treatment for high risk. In 2011, 3163 BMD were performed in the Complejo Asistencial Universitario de León (CAULE). Since the cost for each BMD is 58.6* (BOCYL 31/01/2011), annual spending could rise to *185 352. The aim was to assess whether fracture risk calcu...

Introduction: Generously supported by IPSEN)-->Surgical treatment of pituitary adenomas (PA) may affect hormone situation.Objective: To evaluate the frequency of hypopituitarism and investigate the potential predictors of worsening or improving pituitary function after PA surgery.Methods: Retrospective analysis of all PA operated in our hospital between 2001 and 2010.<p class="abstext...

Background: Strokes are more and more frequent in the world, particularly in Africa. The evolution of their magnitude remains still poorly documented in the context of Burkina Faso, particularly in Bobo-Dioulasso. That is why this study was conducted to clarify the epidemiology of stroke and its risk factors in order to raise the alarm.Objective: Investigate the evolution of the magnitude of stroke and its risk factors at the Teaching Hospital of Bobo-Di...