Endocrine Abstracts

Introduction: The autosomal dominant multiple endocrine neoplasia type 1 (MEN1), characterized by parathyroid hyperplasia (PH), neuroendocrine digestive tumours (NET) and pituitary adenomas (PA), is due to mutations in the tumor suppressor gene MEN1 encoding a 610-amino acid protein, menin. Guidelines recommend MEN1 mutational analysis in index cases with two or more MEN1-associated tumours, in first-degree relatives of mutation carriers and when clinical dat...

Introduction / Background: Patients with advanced GEP-NENs often present with metabolic disorders and oncological treatments may increase malnutrition risk as well as alterations on body composition. Several studies have suggested that sarcopenia is independently associated with a worse prognosis in oncological patients. Sarcopenia predicts survival regardless of body weight; moreover, a reduced muscle mass is not only observed in cachectic individuals but also in overweight p...

Objectives: 1.-Characterization of patients with tall cell variant papillary thyroid carcinoma (TCV-PTC) at diagnosis (Dx) compared to patients with classic papillary thyroid carcinoma (c-PTC);2.-Evaluation of response to therapy (RT) in the (TCV-PTC) cohortExperimental design: Retrospective observational studyMaterials and methods: Patients submitted to surgery for PTC in our institution since 2010 were eval...

Introduction: PTC patients with lymph node (LN) metastases of greater volume (in>5 LN and/or with larger metastases >5mm, hereinafter N1>5) usually receive radioiodine (RAI). Some guidelines suggest carrying out an evaluation of the response to surgical treatment (RST), recommending lower RAI dose (activity) in patients with good RST.Objectives: a)To evaluate the RST in patients with PTC and N1>5 b)To evaluate the disease-free-survival (D...

Background: SGPL1 carries out the final degradative step of the sphingolipid pathway, irreversible cleavage of sphingosine-1-phopshate. SGPL1 deficiency is associated with a pathological accumulation of sphingolipid species and a multi-systemic condition incorporating primary adrenal insufficiency (PAI). Sphingolipid intermediates, ceramide and sphingosine are postulated to act as modulators of the steroidogenic pathway, acting as second messengers altering downstream expressi...

‘Diabesity’ is the term for diabetes occurring in the context of obesity. Obesity is a cardiovascular major risk factor. The National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII) report designated diabetes as a coronary heart disease equivalent. Cardiovascular disease is the leading cause of death in women. The ‘Estudio Epidemiologico de la Mujer’ (EEM) study aimed to explore obesity, diabetes and diabesity in 3500 women over 18 yea...

Thyroid carcinoma is the most common endocrine malignancy. However, the absence of prognostic markers for identified well-differentiated tumors versus undifferentiated/anaplastic or poorly differentiated enhances of the progression of recurrent forms with an unfavorable prognosis. In order to identify potential markers for thyroid cancer prognosis prediction, we analyzed by cDNA micro-array the gene expression profile of tumors of the thyroid, with different degrees of maligna...

Introduction: Information regarding eating disorders (ED) in postsurgical outcomes after bariatric surgery (BS) is scarce.Objectives: To analyze the effect of BS on ED and to investigate if ED influence clinical, biochemical or psychological outcomes.Methods: Sixty patients (78.3%♀, age 46.35±9.89, months since BS 46.28±28.1) who underwent BS, with a minimum follow up of 12 months, were evaluated cross-sectionally. ...

Background and Objective: In thyroid cancer (TC) central compartment (CC) neck dissection (CCND) should accompany thyroidectomy in case of clinical and/or cytological suspicion of lymph node (LN) metastases. Cervical ultrasound has been indicated as the first-line examination in the pre-operative staging of TC, although its diagnostic performance in evaluating CC LN is controversial. Proving that cervical ultrasound can accurately identify CC metastases would allow to use this...

The 2013 guideline (NHLBI ATP IV) on the treatment of blood cholesterol in adults was recently published. It focuses on identification of 4 Statin Benefit Groups (4SBG), in which the potential for Atherosclerotic Cardiovascular Disease (ASCVD) risk reduction benefit clearly exceeds the potential for adverse effects.Objective: To estimate the prevalence of 4SBG among Venezuelan women and to determine its association with hypertension, BMI, waist circumfer...