Endocrine Abstracts

19 years-old female was diagnosed with thyrotoxicosis for the first time in 2015; Severe hypothyroidism developed after 1 month thiamazole therapy, therefore medication was stopped and the patient was prescribed L-T4 that resulted in improvement of thyroid function tests. L-T4 was finally withdrawn and TSH returned to normal. Since then TSH was constantly monitored and the levels were normal. In 01/2020, the patient was presented with complains about increased heart rate, emot...

Title: Pulmonary Embolism in Surgically Treated Cushing’s Disease: A Case ReportAuthors: Qetevan Gvazava1, Nino Zavrashvili1, Natia Margvelashvili2, Natia Shonia2, Ketevan Chanturishvili2 Endocrinology Department, Tbilisi Institute of MedicineBackground: Cushing’s disease is the most common cause of Cushing’s syndrome but can be very difficult to diagnose and to treat. as we know it has numerous health effects on pat...

Background: There is preliminary evidence that prenatal maternal stress (PNMS) is a risk factor for attention deficit hyperactivity disorder (ADHD). Vitamin D deficiency during critical periods of development could lead to persistent brain alterations. Some studies support the hypothesis that prenatal Testosterone exposure contributes to the development of ADHD in children. This study aimed to investigate the hypothesis, that presence of prenatal maternal stress, increased lev...

Purpose: Obesity is a serious health problem that has reached very high proportions in our country; prevalence of obesity and overweight together is 56%. Obesity is strongly associated with risk factors for cardio and cerebrovascular disease, AH, type 2 diabetes and cognitive disorders. The aim of our study was to analyze the impact of AH and weight change on carotid artery intima-media thickness (IMT) and cognitive function in Georgian nondiabetic obese and overweight hyperte...

Autoimmune polyglandular syndromes (APS) are a group of immune-endocrine syndromes that cause autoimmune destruction of multiple endocrine organs. The most common in this group is APS type 2, which frequently presents with primary adrenal insufficiency with autoimmune thyroid disease and/or type 1 diabetes mellitus. We present a case of 46 year old male, with no significant medical history who presented in our clinic with: weakness, fatigue and weight loss for the preceding la...

Context: Hypothalamic-pituitary-adrenal axis (HPA) may be disrupted by drugs, including opioids. Opioids are widely used for treatment of acute and chronic pain, but they also carry a wide range of adverse effects. Opioid receptors are present in the pituitary gland and hypothalamus and chronic use of opioids may lead to adrenal insufficiency because of central suppression of the hypothalamic-pituitary-adrenal axis (HPA).Case Presentation: We report a 26...

Context: Pregnancy and lactation -associated osteoporosis (PLO) is an uncommon condition affecting women during late pregnancy and the early postpartum period. PLO is manifested with fractures usually in spine or occasionally in the hip with severe and prolonged pain and height loss. Pathogenesis of this rare condition is still not completely understood.Case Presentation: We report a 28 y/o female patient presenting with severe back pain during postpartu...

Introduction: Glucocorticoids are widely used for their anti-inflammatory and immunosuppressive properties. Prolonged administration of synthetic glucocorticoids is one of the most common cause of ACTH deficiency and consequent adrenal insufficiency. Exogenous glucocorticoids interfere with and suppress HPA axis and abrupt steroid withdrawal leaves body susceptible to adrenal insufficiency. Symptoms can range from adrenal crisis to nonspecific complains of fatigue, nausea and ...

Background: Primary aldosteronism (PA) is a group of disorders characterized with inappropriately high adrenal aldosterone production, suppressed renin and hypertension. Prevalence of PA is approximately 5-10% in people with hypertension and up to 20-50% in those with resistant hypertension. PA is associated with increased cardiovascular and cerebrovascular morbidity and mortality rates compared with patients with essential hypertension when matched with age, sex and blood pre...

Pituitary apoplexy (PA) is a rare clinical syndrome related to abrupt hemorrhage and/or infarction of the pituitary gland, usually occurring in patients with preexisting pituitary disease. It is an endocrine emergency requiring rapid diagnosis and appropriate management. Pituitary apoplexy may lead to multiple pituitary hormone deficiencies. Without proper diagnosis and management, these can lead to the occurrence of irreversible complications, most significantly adrenal crisi...