Endocrine Abstracts

IntroductionDiffuse optic techniques exploit the capability of penetration of near infrared light to investigate the properties and physiology of tissues. Based on this property, the LUCA device (Laser and Ultrasound Co-Analyzer of Thyroid nodules), a multi-modal device that combines two different diffuse optical techniques – time resolved and diffuse correlation spectroscopies – with ultrasound in the same transducer, has been developed with t...

Purpose: From a clinical perspective, the full spectrum of Sars–CoV–2–infected patients has not yet been defined. This study aimed to evaluate whether liver density on computed tomography (CT) scan and serum insulin-like growth factor 1 (IGF1) values can explain the clinical variability of COVID–19 cases.Methods: We performed a retrospective study including SARS–CoV–2–infected patients hospitalized from March 2020 to Ma...

Introduction: The use of multigene panels in thyroid nodule diagnosis is still limited, due to high costs and need for ad hoc sampling. Since BRAF-V600E is the commonest genetic alteration in differentiated thyroid cancer, this is the mostly tested genetic parameter in clinical practice.Aim: To evaluate the use of BRAF mutation analysis in wash-out liquid from fine needle aspiration (FNA) in clinical practice, characterizing th...

Abstract unavailable...

Sex steroid hormone-induced variations of vascular smooth muscle cells (VSMCs) migration are critical in determining the sex/gender-related differences in male and female pathophysiology of cardiovascular system. Although several substances present in the environment, defined endocrine disruptors (EDs), could interfere with androgen and estrogen effects, the sex/gender-related susceptibility of VSMC motility to these substances is completely unknown. Here, naringenin (Nar) and...

The high morbidity and mortality rate of women with Turner syndrome (TS) is primarily a results of the cardiovascular complications and so it is necessary an accurate and precocious diagnosis of this disease. Congenital cardiac anomalies, whose causes remains unknown, are common in TS (21–40%), in particular among patients with 45 X; between these the ventricular septal defect (VSD) is very rare (in a recent review, 3/1092 cases) (Gravholt 2004) and so in neonatal with VS...

Oxidative stress (OS) can have an impact both in the pathogenesis and in the progression of TC, as it has been shown to induce oncogenes and inhibit tumor suppressors. The main source of cellular ROS is represented by NADPH oxidases (NOXs). Aims of the study were to investigate the NOX-derived OS in TC samples, benign nodules and corresponding normal tissues, and to correlate the level of OS with histological classification, genetic profile and clinical and prognostic features...

TERT is the protein component of the telomerase enzyme and is overexpressed in many cancer types. The most well-known role for TERT is the regeneration of telomeres allowing the avoidance of senescence and the continued proliferation of stem and cancer cells. Recent studies have identified other roles for TERT in compartments outside the nucleus, in particular in mitochondria, with a protective role against endogenous and therapy-induced oxidative stress (OS). A small subset o...

Recent years have seen an increasing effort to decode the cancer genome. Most of the studies have focused on the coding genome to identify cancer driver genes. My group is interested in the role of the non-coding genome and its potential contribution to the drive transcriptional aberrations in breast cancer patients. To do so we use a wide-spectrum of techniques including genomic, epigenomics in patient-derived samples. I will present the results of a couple of studies in whic...

The central hypothyroidism (CeH) is a hypothyroid condition due to an insufficient stimulation by TSH of an otherwise normal thyroid gland. CeH is about 1000-fold rarer than primary hypothyroidism (PH). Differently to PH, the CeH is most frequently characterized by low/normal TSH levels and thyroid hormone replacement is associated with the suppression of residual TSH secretion even during low thyroxine regimen.Thus, CH management often represents a clin...