Endocrine Abstracts

Background: Acromegaly is an orphan neuroendocrine disease characterized by a variety of complications. Due to slow symptom progression acromegalic patients often are involved in growth hormone complications correction for a long time instead of search for main cause of these multiple disorders. A view on conductive hearing loss in acromegaly in literature is contradictory. The low incidence of hearing in acromegaly, compared with other complications, is presumably due to the ...

Introduction: The calcific uremic arteriolopathy (CUA) is one of the several types of extra-osseous calcification that may occur in patients with end-stage renal disease (ESRD). CUA is a serious disorder characterized by calcification of the arterioles that leads to ischemia and subcutaneous necrosis. The pathogenesis is poorly understood, and the optimal treatment is not known.Case report: We present the case of a 64-year-old female with ESRD on hemodia...

In Ukraine, in 2017, an estimated 53000 people were living with chronic hepatitis C virus (HCV) infection, and its prevalence rate was 123.7 patients per 100000 citizens. Symptoms of at least one extra hepatic manifestations appear in more than 50% of HCV-positive patients, and thyroid abnormalities are rather common. The purpose of the study was to determine the prevalence of thyroid function tests and anti-thyroid autoantibodies abnormalities in the untreated patients with c...

Combination of coronary heart disease (CHD) with diabetes mellitus type 2 significantly increases the risk of left ventricular remodeling. The objective of the study was to determine the association of biomarkers of myocardial fibrosis with the level of glycaemia at CHD in patients with and without DM type 2.Methods: We have examined 104 patients with CHD of everage age 64.9±0.3 years old, 27 of them were with DM type 2; 77 patients were without DM ...

Diabetic foot syndrome (DFS) is currently considered the most severe of all late diabetes complications, resulting in deteriorating health outcomes, increased disability and reduced life expectancy.Aim: To study the frequency of occurrence of DFS in rural peoples with diabetes in Uzbekistan.Methods: Upon the international project WDF08-379 ‘Prevention of lower limb amputations in people with diabetes in Uzbekistan’, imple...

Of all the late complications of diabetes, foot lesions are the most preventable. The multidisciplinary approach to providing specialized help for people with diabetes can prevent the amputations in 49–85% diabetic foots.Aim: The organization of specialized help to patient with diabetic foot syndrome (DFS) by the establishing the network of ‘Diabetic foot’ rooms and training of multidisciplinary team of specialists (endocrinologist, surgeo...

Goal: Decrease a number of lower limb amputations in PDM in Uzbekistan by improvement of specialised help given to patients with DFS.Materials and methods: Prior to 2010 there were only 2 ‘Diabetic foot’ rooms in Tashkent, Uzbekistan. In 2010–2012, CPA ‘UMID’ jointly with Uzbekistan Ministry of Health and Research Centre for Endocrinology implemented a project ‘Prevention of lower limb amputations in people with diabetes mel...

Goal: Decrease a number of lower limb amputations in PDM in Uzbekistan by improvement of specialised help given to patients with DFS.Materials and methods: Prior to 2010 there were only 2 ‘Diabetic foot’ rooms in Tashkent, Uzbekistan. In 2010–2012, ‘UMID’ association jointly with Uzbekistan Ministry of Health and Research Centre for Endocrinology implemented a project ‘Prevention of lower limb amputations in people with diab...

Goal: To study occurrence frequency of diabetic foot syndrome (DFS) in three pilot regions of Uzbekistan.Material and methods: Upon WDF project, ‘UMID’ Association of Tashkent and RRPMCE have screened T1DM and T2DM patients for DFS in three pilot regions (Andizhan, Tashkent, and Kashkadarya areas). 663 patients examined; of them 581 T2DM patients and 82 T1DM peoples in the 25–65 age groups with duration of the disease 5–15 years. Resu...

Factors affecting the development of nephrolithiasis (NL) in primary hyperparathyroidism (PHPT) actively studied. CASR polymorphisms may be linked with the development of NL in PHPT. Supposed to the role of VDR in the development of nephrolithiasis in patients without PHPT.Objective: To assess the relationship of polymorphisms CASR and VDR with the development of the NL at PGPT.Methods: The study included 187 patients with PTPT (54...