Endocrine Abstracts

Background: Acinic cell carcinoma of the parotid gland is a rare cancer, and metastatic (M1) disease is uncommon, occurring in around 10% of cases, with ectopic paraneoplastic Cushing being described in only few cases.Clinical case: A 58-year-old woman, with a history of dedifferentiated parotid acinar cell carcinoma, underwent surgery and adjuvant radiotherapy in 2005. In February 2019 the disease recurred with pulmonary, bone and lymph node metastases....

Most thyroid nodules are benign and majority do not require treatment, except for those large nodules that cause symptoms (compression, hormonal dysfunction and/or esthetic problems). Microwave ablation (MWA) is an attractive therapeutic option because it is minimally invasive, relatively inexpensive, capable of providing coagulative necrosis, and has a short treatment time. In the following, we present the experience of our hospital.Objective: To evalua...

Objectives: Most transgender persons (0.3-0.5% of total population) are under gender-affirming hormone therapy (GAHT). Several studies have reported an increased morbimortality due to cardiovascular events (CVE), infectious disease and suicide. However, these studies were made on small populations and short follow up. We evaluated the changes on anthropometric variables, risk factors for cardiovascular diseases (CVD) and CVE at 5 and 10 years of follow up in a transgender popu...

Introduction: The Neuroendocrine Tumors Study Group of the Portuguese Endocrine Society (SPEDM) performed the first observational study between November 2012 and July 2014 too assess the profile of Gastroenteropancreatic Neuroendocrine Tumours (GEP-NET) patients (pts) followed at the main Portuguese hospitals. Several demographic and clinical data were collectedObjective: Characterize the clinicopathological features and treatment of patients with NET or...

Introduction: Giant pituitary adenomas (GPAs) are traditionally defined as the tumors with the greatest diameter at or above 40 mm. However, some clinical series of GPAs include tumors with maximal diameter of 35 to 40 mm, and those tumors can be named ‘nearly giant’ pituitary adenomas (nearly GPAs). The treatment of GPAs is challenging and has a higher risk of complications due to the size and complex anatomical relations. This study was conducted to compare GPAs an...

Introduction: Cushing’s disease (CD) is responsible for 80% of endogenous Cushing’s syndrome (CS). However, distinguishing the cause of ACTH-dependent CS – CD vs ectopic CS – can be extremely difficult. Bilateral inferior petrosal sinus sampling (IPSS) has the highest diagnostic accuracy in this evaluation.Objectives: The aims of this study were to determine the accuracy of bilateral IPSS in the differential diagnosis of ACTH-dependen...

Introduction: Gain of function mutations of RET protooncogene are associated with hereditary medullary thyrpoid cancer. There are mainly specific hot-spot RET gene mutations however they may differ between population.Aim of the study: In this study we report the prevalence of RET mutations in Polish population based on 20 years of experience of referral polish centers.Material and methods: RET ge...

A personalized patient treatment regimen for endogenous Cushing’s syndrome (CS) should be developed by a specialized multidisciplinary team, taking patient values and preferences into consideration. Comorbidities, which may compromise patient health and QoL need to be addressed, in many cases concomitant with or even before CS-specific treatments to restore eucortisolemia. Treatment of endogenous CS is initially primarily surgical and aims at complete resection of the und...

Background: 38% of teens use social media more than once an hour and 16% use it almost constantly (Rideout, 2018). Even so, the connection between smartphone use and nutrition and eating disorders is understudied and merits further study. Therefore, this study aims to examine the associations between smartphone use and eating disorders among adolescents.Methods: The study enrolled 325 participants aged 14-19 years in Florida, US, with 46% (n=150...

Microbiota plays a major role in health and disease in humans. Sex hormones influence the diversity and composition of the gut microbiota. Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age (6–20%). PCOS is characterized by the association of androgen excess with oligomenorrhea, anovulatory infertility, and increased metabolic risk factors. The study of the interaction between gut microbiota and sex hormones in PCOS coul...