Endocrine Abstracts

Introduction: Different studies have published that testosterone therapy in men and women results in decreased HDL cholesterol and increased LDL cholesterol, and therefore an increased cardiovascular risk.Aims: To determine whether testosterone therapy has this effect on lipid parameters and markers of metabolic syndrome (MetSyn) in female-to-male transsexuals (FMT).Material and methods: We studied 50 FMT, aged 27.8±7.6 years,...

Prevalence of hyperandrogenism (HA) and polycystic ovary syndrome (PCOS) in female to male transsexuals (FMT) is controversial. To known the prevalence of hyperandrogenism and PCOS in FMT, and their relation with insulin resistance (IR) and other cardiovascular risk factors (CVRF), we studied 77 Spanish consecutive FMT cases, the first ones who appeared in our Gender Unit between May 2007 and Dec 2008, aged 18–43 years. The subjects had never received hormonal treatment o...

Background: Endothelial dysfunction may have deleterious effect cardiovascular pathology in diabetic patients.Atrial natriuretic peptide (ANP) exerts beneficial effects on the cardiovascular system in part by exerting antioxidant activity. Recently it was reported that ANP is able to exert an antihypertrophic effect in myocitos at least in part due to inhibition of NADPH oxidase and superoxido generation.It seems that hyperglucemia...

Introduction: Paragangliomas and pheochromocytomas (PGGs) are infrequent tumors of the autonomic nervous system that represent a diagnostic and therapeutic challenge. Management and follow-up of PGGs requires specialized knowledge and solid experience, which, given the rarity of these diseases, is available only in highly specialized centers. University Hospital La Fe (Spain) was designated a reference unit on Neuroendocrine Tumors by local sanitary authorities in 2018. The ai...

Context: There is no data on mortality of acromegaly diagnosed in the elderly. Objective: To compare clinical characteristics, GH-related comorbidities, therapeutic approaches and mortality of patients diagnosed before or after 2010 and to assess overall mortality compared with the general Spanish population. Setting: Spanish tertiary care centers.Design, Patients, and Methods: Retrospective evaluation of 118...

C-type natriuretic peptide (CNP) represents a key paracrine member of the natriuretic peptide family that play an important role in the regulation of vascular tone and local blood flow. CNP is found abundantly in vascular endothelial cells and it is now clear that CNP can be released from the endothelium to act on adjacent cells, both in the vessel wall and the circulation. Thus, it has been shown that CNP hyperpolarises and dilates vascular smooth muscle in the mammalian resi...

Introduction: Cushing’s disease (CD) is responsible for 80% of endogenous Cushing’s syndrome (CS). However, distinguishing the cause of ACTH-dependent CS – CD vs ectopic CS – can be extremely difficult. Bilateral inferior petrosal sinus sampling (IPSS) has the highest diagnostic accuracy in this evaluation.Objectives: The aims of this study were to determine the accuracy of bilateral IPSS in the differential diagnosis of ACTH-dependen...

Introduction: The syndrome of late-onset hypogonadism (LOH) is a clinical and biochemical syndrome associated with advancing age male, characterized by typical symptoms and decreased serum concentrations of testosterone, which can affect multiple organ systems and may impair quality of life. The prevalence of LOH syndrome is higher in certain patient groups, obese, diabetic and suffering from erectile dysfunction manifest LOH at higher rates than the general population.<p ...

Introduction: During a normal menstrual cycle, serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), and progesterone (P4) can vary widely between cycles for the same woman, as well as between different women. Reliable reference values based on the local population are important for correct interpretation of laboratory results.Aims: To evaluate the discrepancy of the results on fertility hormones by two different t...

Androgen deficiency in the aging male has become an actual topic due to the aging population and finding from different studies that shown a progressive decline of serum levels of age-related testosterone. These levels have been inversely related with markers of metabolic syndrome and cardiovascular disease.The aim of this observational study was to investigate the relation of endogenous testosterone and other sex hormones with different components of me...